Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 604-453-0 | CAS number: 145022-45-3
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline study conducted according to GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- 1-ethyl-3-methyl-1H-imidazol-3-ium methanesulfonate
- EC Number:
- 604-453-0
- Cas Number:
- 145022-45-3
- Molecular formula:
- C6 H11 N2. C H3 O3 S
- IUPAC Name:
- 1-ethyl-3-methyl-1H-imidazol-3-ium methanesulfonate
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- dimethylformamide
- Concentration:
- 0, 25, 50, and 100%
- No. of animals per dose:
- 5
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: 0%: 1.00 25%: 1.56 50%: 2.46 100%: 2.98
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: 0%: 931.5 25%: 1454.7 50%: 2291.1 100%: 2774.7
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
- Conclusions:
- The test item EMIM Methansulfonate was found to be a weak skin sensitiser under the test conditions of this study.
- Executive summary:
In order to study a possible skin sensitisation potential of EMIM Methansulfonate, three groups each of five female mice were treated daily with the test item at concentrations of 25, 50, and 100% (w/v) in dimethylformamide by topical application to the dorsum of each ear once daily for three consecutive days. All treated animals survived the scheduled study period and no signs of systemic toxicity or local skin irritation were observed.
In this study Stimulation Indices (S.I.) of 1.56, 2.46, and 2.98 were determined with the test item at concentrations of 25, 50 and 100% (w/v) in dimethylformamide, respectively. A clear dose response was observed. The EC3 value calculated was about 100% (w/v).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
