Registration Dossier
Registration Dossier
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EC number: 230-049-5 | CAS number: 6925-69-5
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Allergic contact dermatitis from a perinone-type dye C.I. Solvent Orange 60 in spectacle frames
- Author:
- Shono M, Kaniwa MA
- Year:
- 1 999
- Bibliographic source:
- Contact Dermatitis, 41, 181-184
- Reference Type:
- publication
- Title:
- Allergic contact dermatitis from a perinone-type dye C.I. Solvent Red 179 in spectacle frames
- Author:
- Tsunoda T, Kaniwa MA, Shono M
- Year:
- 2 001
- Bibliographic source:
- Contact Dermatitis, 45, 166-167
- Reference Type:
- publication
- Title:
- Allergic contact dermatitis caused by Solvent Orange 60 dye
- Author:
- Yeo L, Kuuliala O, White IR, Alto-Korte K
- Year:
- 2 011
- Bibliographic source:
- Contact Dermatitis 64, 353-36
- Reference Type:
- publication
- Title:
- Allergic contact dermatitis from solvent orange 60 in spectacle frames
- Author:
- Isaksson M, Helwig H, Zimerson E, Ryberg K, Hagvall L
- Year:
- 2 012
- Bibliographic source:
- Contact Dermatitis 66 (Suppl.2), 77
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
- Principles of method if other than guideline:
- In case reports the development of dermatitis over the ears was reported after wearing of spectacle frames with earpieces of plastic material containing C.I. Solvent Orange 60. The patients were patch tested and and reacted positive on C.I. Solvent Orange 60. In one case report of a woman working in a plastic manufacturing company the development of dermatitis affecting the wrist, fingers and face was reported. The patient reacted positive in patch tests using C.I. Solvent Orange 60.
- GLP compliance:
- no
Test material
- Reference substance name:
- 12H-phthaloperin-12-one
- EC Number:
- 230-049-5
- EC Name:
- 12H-phthaloperin-12-one
- Cas Number:
- 6925-69-5
- Molecular formula:
- C18H10N2O
- IUPAC Name:
- 12H-phthaloperin-12-one
Constituent 1
Method
- Type of population:
- general
- occupational
- Subjects:
- Humans
- Route of administration:
- dermal
- Details on study design:
- Patch test
Results and discussion
- Results of examinations:
- Four patients with contact dermatitis reacted positive in patch tests with C.I. Solvent Orange 60.
Applicant's summary and conclusion
- Executive summary:
In case reports the development of dermatitis over the ears was reported after wearing of spectacle frames with earpieces of plastic material containing C.I. Solvent Orange 60. The patients were patch tested and and reacted positive on C.I. Solvent Orange 60. In one case report of a woman working in a plastic manufacturing company the development of dermatitis affecting the wrist, fingers and face was reported. The patient reacted positive in patch tests using C.I. Solvent Orange 60.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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