12H-phthaloperin-12-one

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

Experimental data of test chemicals

Justification for type of information:

Data for the test chemical is from peer reviewed journal

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

WoE report is based on two short term toxicity study of fish for the test chemical :

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

other: 1) Oncorhynchus mykiss 2) Ictalurus punctatus

Details on test organisms:

1st: - Common name: Rainbow trout
2: - Common name: Channel Catfish
- Weight: 1.3 g

Test type:

static

Water media type:

freshwater

Total exposure duration:

96 h

Reference substance (positive control):

no

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

2.8 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: 1st study

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

2.09 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: 2nd study

Validity criteria fulfilled:

no

Conclusions:

1: Based on the mortality rate of fish Oncorhynchus mykiss by the chemical exposure for 96 hrs, the LC50 was observed at 2.8 mg/L.
2: Based on the mortality rate of fish Oncorhynchus mykiss by the chemical exposure for 96 hrs, the LC50 was observed at 2.09 mg/L.

Executive summary:

Data available for the test chemicals has been reviewed to determine the short term toxicity of the test chemical on the mortality of fish.The studies are as mentioned below:

In the first study test material was subjected to evaluate its acute toxicity effect on Oncorhynchus mykiss. Aim of this study was determine the effect of test chemical on the mortality of fish Oncorhynchus mykiss. Test conducted under the static system for 96 hrs. Based on the mortality rate of fish Oncorhynchus mykiss by the chemical exposure for 96 hrs, the LC50 was observed at 2.8 mg/L.

Above results were supported by the second experimental study from authoritative database. Aim of this study was determine the effect of test chemical on the mortality of fish Ictalurus punctatus (Channel Catfish). Test conducted under the static system for 96 hrs. 1.3 g channel catfish were used in the study. Based on the mortality rate of fish Ictalurus punctatus(Channel Catfish) by the chemical exposure for 96 hrs, the LC50 was observed at 2.09 mg/L.

Based on the above results, chemical can be consider to be toxic, however the obtained median letal concentration is very much higher than the solubility of the test chemical. Thus considering water solubility and toxicity values test chemical can be categorised into not classified category.

Description of key information

1: Based on the mortality rate of fish Oncorhynchus mykiss by the chemical exposure for 96 hrs, the LC50 was observed at 2.8 mg/L.

2: Based on the mortality rate of fish Oncorhynchus mykiss by the chemical exposure for 96 hrs, the LC50 was observed at 2.09 mg/L.

Based on the above results, chemical can be consider to be toxic, however the obtained median letal concentration is very much higher than the solubility of the test chemical. Thus considering water solubility and toxicity values test chemical can be categorised into not classified category

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

2.8 mg/L

Additional information

Data available for the test chemical including structually and functionally similar read across chemical has been reviewed to determine the short term toxicity of the test chemical on the mortality of fish.The studies are as mentioned below:

In the first study test material was subjected to evaluate its acute toxicity effect onOncorhynchus mykiss. Aim of this study was determine the effect of test chemical on the mortality of fish Oncorhynchus mykiss. Test conducted under the static system for 96 hrs. Based on the mortality rate of fish Oncorhynchus mykiss by the chemical exposure for 96 hrs, the LC50 was observed at 2.8 mg/L.

Above results were supported by the second experimental study from authoritative database.Aim of this study was determine the effect of test chemical on the mortality of fish Ictalurus punctatus (Channel Catfish). Test conducted under the static system for 96 hrs. 1.3 g channel catfish were used in the study. Based on the mortality rate of fish Ictalurus punctatus(Channel Catfish) by the chemical exposure for 96 hrs, the LC50 was observed at 2.09 mg/L.

Based on the above results, chemical can be consider to be toxic, however the obtained median letal concentration is very much higher than the solubility of the test chemical. Thus considering water solubility and toxicity values test chemical can be categorised into not classified category