12H-phthaloperin-12-one

Long-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

accepted calculation method

Justification for type of information:

Data is from ECOSAR

Qualifier:

according to guideline

Guideline:

other: Modeling database

Principles of method if other than guideline:

Long term toxicity of test chemical were determine on the freshwater aquatic invertebrate daphnia magna.

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

Daphnia magna

Details on test organisms:

- Water flea

Test type:

flow-through

Water media type:

not specified

Total exposure duration:

21 d

Reference substance (positive control):

not specified

Key result

Duration:

21 d

Dose descriptor:

NOEC

Effect conc.:

1.534 mg/L

Nominal / measured:

estimated

Conc. based on:

test mat.

Basis for effect:

immobilisation

Remarks on result:

other: Other details not known

Validity criteria fulfilled:

not specified

Conclusions:

On the basis of effects observed in a freshwater system, the NOEC value for the substance is estimated to be 1.534 mg/l for aquatic invertebrate for 21 days of exposure duration.

Executive summary:

Based on the prediction done using ECOSAR version, the long term toxicity on aquatic invertebrate was predicted for test substance. On the basis of effects observed in a flow-through freshwater system, the NOEC value for the substance is estimated to be 1.534 mg/l for aquatic invertebrate for 21 days of exposure duration. Since, it can be concluded that the test chemical can be considered as non-toxic to aquatic invertebrate at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria.

Description of key information

Based on the prediction done using ECOSAR, the long term toxicity on aquatic invertebrate was predicted for test substance. On the basis of effects observed in a flow-through freshwater system, the NOEC value for the substance is estimated to be 1.534 mg/l for aquatic invertebrate for 21 days of exposure duration. Since, it can be concluded that the test chemical can be considered as non-toxic to aquatic invertebrate at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

1.534 mg/L

Additional information

Data available for test chemicals including structurally and functionally similar read across chemical, study has been reviewed to determine the long term toxicity of the test chemical on the growth and reproduction of daphnia magna. The studies are as mentioned below:

 

Based on the prediction done using ECOSAR version, the long term toxicity on aquatic invertebrate was predicted for test substance. On the basis of effects observed in a flow-through freshwater system, the NOEC value for the substance is estimated to be 1.534 mg/l for aquatic invertebrate for 21 days of exposure duration. Since, it can be concluded that the test chemical can be considered as non-toxic to aquatic invertebrate at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria.

 

Long term toxicity of test chemical were studied on the reproduction of test organism daphnia magna. Test conducted in accordance with OECD Test Guideline 202. 5 nominal concentrations (0.78-78 mg/l) were used for the study and performed under the closed static system. 9:1 DMSO:HCO-40 used as a vehicle. 4 replicates; 10 organisms per replicate) were exposed at the nominal concentrations. Effects were observed in the interval of 24 hrs, 48 hrs, 72 hrs, 96 hrs, 7 days and 14 days. Based on the effects observed on the mortality and reproduction of freshwater daphnia magna by the test chemical effects were observed. On the basis of mortality, the LC50 after 21 days were determine to be 2.6 mg/l and on the basis of effects on reproduction, the EC50 was 1.6 mg/l. The NOEC was observed at 0.78 mg/l and LOEC at 2.5 mg/l. Based on the LC50 and EC50, chemical consider to be nontoxic and not classified as per the CLP classification criteria.

 

Thus based on the EC50 and LC50, chemical consider to be nontoxic and not classified as per the CLP classification criteria.