2-(2-chloroethoxy)ethanol

Endpoint summary

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records

Reference

Endpoint:

skin sensitisation: in vivo (non-LLNA)

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Justification for type of information:

QSAR prediction: migrated from IUCLID 5.6

Qualifier:

according to guideline

Guideline:

other: estimated data

Principles of method if other than guideline:

Prediction is done using QSAR Toolbox version 2.3

GLP compliance:

no

Type of study:

Draize test

Species:

human

Strain:

not specified

Sex:

not specified

Route:

other: no data

Vehicle:

no data

Route:

other: no data

Vehicle:

no data

Positive control substance(s):

not specified

Reading:

1st reading

Group:

test chemical

No. with + reactions:

0

Clinical observations:

negative skin sensitization

Remarks on result:

other: Reading: 1st reading. Group: test group. No with. + reactions: 0.0. Clinical observations: negative skin sensitization.

The prediction was based on dataset comprised from the following descriptors: "Skin sensitisation"
Estimation method: Taking highest mode value from the 5 nearest neighbours
Domain logical expression:Result: In Domain

(((("a" and "b" ) and ("c" and ( not "d") ) ) and ("e" and ( not "f") ) ) and ("g" and "h" ) )

Domain logical expression index: "a"

Similarity boundary:Target: C(Cl)COCCO
Threshold=50%,
Dice(Atom pairs)

Domain logical expression index: "b"

Similarity boundary:Target: C(Cl)COCCO
Threshold=60%,
Dice(Atom pairs)

Domain logical expression index: "c"

Referential boundary: The target chemical should be classified as Inclusion rules not met by Skin irritation/corrosion Inclusion rules by BfR

Domain logical expression index: "d"

Referential boundary: The target chemical should be classified as Aldehydes OR Ketones by Skin irritation/corrosion Inclusion rules by BfR

Domain logical expression index: "e"

Referential boundary: The target chemical should be classified as No alert found by Protein binding by OASIS

Domain logical expression index: "f"

Referential boundary: The target chemical should be classified as Activated alkyl esters OR alpha,beta-carbonyl compounds with polarized double bonds OR Epoxides, Aziridines and Sulfuranes OR MA: Interchange reaction with sulphur containing compounds OR MA: Michael addition on conjugated systems with electron withdrawing group OR MA: Nucleophilic substitution at sp3 Carbon atom OR MA: Ring opening SN2 reaction OR Mechanistic Domain: Michael addition OR Mechanistic Domain: SN2 OR Thiols and disulfide compounds by Protein binding by OASIS

Domain logical expression index: "g"

Parametric boundary:The target chemical should have a value of log Kow which is >= -0.417

Domain logical expression index: "h"

Parametric boundary:The target chemical should have a value of log Kow which is <= 0.568

Interpretation of results:

not sensitising

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The substance 2-(2-chloroethoxy)ethanol was found to be non sensitizing to skin of human.

Executive summary:

The substance 2-(2-chloroethoxy)ethanol was found to be non sensitizing to skin of human and thus it can be indicated that the substance will not be classified in any of the category as per the regulation.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not sensitising)

Additional information:

The substance 2-(2-chloroethoxy)ethanol was found to be non sensitizing to skin of human and thus it can be indicated that the substance will not be classified in any of the category as per the regulation.

Migrated from Short description of key information:

The substance 2-(2-chloroethoxy)ethanol was found to be non sensitizing to skin of human

Justification for selection of skin sensitisation endpoint:

The substance 2-(2-chloroethoxy)ethanol was found to be non sensitizing to skin of human

Justification for classification or non-classification

The substance 2-(2-chloroethoxy)ethanol was found to be non sensitizing and so will not be classified in any of the category as per the regulation.

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