Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Additional information

C16-18 DMAPA amidoamine is a strong base which under environmental conditions is mostly protonated and therefore a cationic surfactant (e.g. at pH 7 99.6% of the tertiary amine is protonated). For cationic surfactants log Kow cannot be measured reliably. Therefore the cmc and the octanol solubility of the protonated amine was measured and the log Kow calculated to 2.01 at pH 7. Based on this low log Kow it can be concluded that the registration substance has a low potential for bioaccumulation and magnification. In addition the registration substance is readily biodegradable and it can be assumed that also metabolism in fish takes place which influences the BCF as well.

Based on these data it is not warranted to perform an OECD 305 Fish BCF study in accordance with REACH regulation, Annex IX, 9.3.2, column 2.


However, a QSAR calculation is additionally presented: The BCF of the main constituents of C16-18 DMAPA amidoamine have been calculated using EPIWIN v4.11, BCFBAF v3.01, Arnot-Gobas BCF & BAF Methods.

Assuming a biotransformation rate of zero, the BCF of N-(3-(dimethylamino)propyl)-hexadecanamide as well as N-(3-(dimethylamino)propyl)-octadecanamide was 11.83 L/kg.

Including biotransformation rate estimates, the BCF of N-(3-(dimethylamino)propyl)-hexadecanamide was in the range of 2.73 - 3.11 L/kg; the BCF of N-(3-(dimethylamino)propyl)-octadecanamide was on the range of 2.65 - 3.03 L/kg.