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Physical & Chemical properties

Solubility in organic solvents / fat solubility

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The following results from supporting substances are used for justification of read-across:

The solubility of Stearic acid 3-(dimethylaminopropyl)amide in n-Octanol was determined according to OECD guideline 105, 27 July 1995, adapted for n-Octanol (flask method). The solubility of Stearic acid 3-(dimethylaminopropyl)amide in n-Octanol is 151 g/L.

A supporting study is available, in which the solubility of Stearic acid 3-(dimethylaminopropyl)amide in n-Octanol was determined by HPLC/CAD.

The average solubility of Stearic acid 3-(dimethylaminopropyl)amide in n-Octanol was 21.6 ± 0.98%. The density of the saturated mixture was determined to be 0.832 ± 0.003 g/mL. Using the density, the solubility of Stearic acid 3-(dimethylaminopropyl)amide in n-Octanol can be converted into 180 ± 8 g/L.

The solubility of Stearic acid 3-(dimethylaminopropyl)amide hydrochloride in n-Octanol was determined according to OECD guideline 105, 27 July 1995, adapted for n-Octanol (flask method). The solubility of Stearic acid 3-(dimethylaminopropyl)amide hydrochloride in n-Octanol is 22 g/L.

The solubility of C22-trimethylammoniumchlorid in n-Octanol was determined following the OECD guideline 105 and Directive 92/69/EC Method A.6 (guidelines adapted to the purpose of the study). The solubility of the test item C22-trimethylammoniumchlorid in n-Octanol was determined using the flask method. The test mixtures were incubated at 30 +- 0.5°C for 72, 48 and 24 hours and the solubility was measured after 24 h at 20 +- 0.5°C. The solubility of C22-trimethylammoniumchlorid in n-Octanol was 19.7 g/L at 20°C.