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EC number: 278-855-6
CAS number: 78169-20-7
Acute oral toxicity:acute oral study with rats (BASF, 1971): LD50 = 950 (851 - 1062) mg/kg bw acute oral study with rats (BASF, 1967): LD50 = 1600 mg/kg bwacute oral study with rats (BASF, 1966): LD50 = 1400 mg/kg bwAcute inhalative and dermal toxicity:In accordance with column 2 of REACH Annex VIII, the test on acute dermal toxicity (required in section 8.5) does not need to be conducted as the available information show that the criteria are met for classification as corrosive to the skin (R34, skin corr. cat. 1C). In conclusion, no further testing is required in accordance with animal welfare reasons.
Acute toxicity oral:
Three studies according to a BASF-internal
standard protocol similar to OECD TG 401 were conducted in order to
estimate the acute oral toxicity of the test item. Gross pathology was
performed for all of the treated animals.
1) XXI/132, 1971
During this study 10 rats per sex and dose
were treated with 640, 800, 1000, 1250, 1600, 2000, 2500 or 3200 mg/kg
bw of the test item prepared as 10% aqueous emulsion with CMC. The
composition of test material was reported as 60.0 % glycol sulfate, 17.9
% sulfate and 2.6 % bisulfate of C11-C14-alcyl-(CH2-CH2OH)S+, 19.5 %
C11-C14-alcyl-oxethylsulfide. After application of 2600, 2000, 2500 and
3200 mg/kg bw the animals showed dyspnea, slight trembling spasms,
apathy, diarrhea, secretion out of the oral cavity as well as
red-agglutinated eyes and noses. Treatment with 640, 800, 1000 and 1250
mg/kg bw caused dyspnea and scretion out of the oral cavity while
surviving animals did not show any clinical signs after 6 days. The
animals were observed for 14 days. After 14 days the following mortality
rate was observed: 640 mg/kg: 2/20, 800 mg/kg: 4/20, 1000 mg/kg: 13/20,
1250 mg/kg: 16/20; 1600, 2000, 2500, and 3200 mg/kg: 20/20. Gross
pathological findings were only observed for animals that died during
the study and implied intestine atony, diarrhea, general venous
congestion. The LD50 of 950 mg/kg bw was calculated using the method of
2) XVII/299, 1967
During this study 10 rats per dose level
were treated with 2, 10, 20 and 30% emulsions of the test item in water
resulting in doses of 200, 1250, 1600, 3200, and 6400 mg/kg bw. The
analytical purity of the test item was 50%. The animals were observed
for 7 days while dyspnea and apathy were reported. After 7 days the
following mortalities were detected: 200 mg/kg: no deaths, 1250 mg/kg:
2/10, 1600 mg/kg: 5/10, 3200 and 6400 mg/kg: 10/10. The only gross
pathology finding was diarrhea and the LD50 was estimated to be 1600
During this study 10 rats per dose level
were treated with 2, 8, 16 and 30% emulsions of the test item in water
resulting in doses of 200, 800, 1000, 1250, 1600, 2000, and 3200 mg/kg
bw. The purity of the test item was 90%. The animals were observed for 7
days while the following clinical signs were reported: Excitation,
staggering, dyspnea, diarrhea. Diarrhea was also found during gross
pathology. Based on the following mortalities an LD50 of 1400 mg/kg bw
was estimated: 200 mg/kg: no deaths, 800 mg/kg: 1/10, 1000 mg/kg: no
deaths, 1250 mg/kg: 2/10, 1600 mg/kg: 8/10, 2000 mg/kg: 9/10, 3200
The test item is harmful after oral
administration (EU: R22; GHS acute oral cat. 4, H302) according to the
criteria of EU Directive 67/548/EEC and EU Classification, Labelling and
Packaging of Substances and Mixtures (CLP) Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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