Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
209-136-7
CAS no.:
556-67-2
Index number:
Molecular formula:
C8H24O4Si4
SMILES:
C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1
InChI:
InChI=1S/C8H24O4Si4/c1-13(2)9-14(3,4)11-16(7,8)12-15(5,6)10-13/h1-8H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
14
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the harmonised classification and labelling (ATP15) approved by the European Union, this substance is very toxic to aquatic life with long lasting effects and is suspected of damaging fertility.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is a flammable liquid and vapour, is suspected of damaging fertility or the unborn child and may cause long lasting harmful effects to aquatic life.

Breakdown of all 4506 C&L notifications submitted to ECHA

Repr. 2 H361f Harmonised Classification
Aquatic Chronic 4 H413
Flam. Liq. 3 H226
Aquatic Chronic 2 H411
Aquatic Chronic 1 H410 Harmonised Classification
Not Classified
Acute Tox. 1 H330
Acute Tox. 3 H311
Aquatic Acute 1 H400
Acute Tox. 4 H302
Acute Tox. 4 H312
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • R
Suspected to be Toxic to Reproduction (Harmonised C&L).
  • PBT
Officially recognised in the EU as Persistent, Bioaccumulative and Toxic (Candidate list of SVHCs).
  • PBT
Under assessment as Persistent, Bioaccumulative and Toxic (PBT list).
  • POP
Potentially a Persistent Organic Pollutant ( Substances proposed as POPs ).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 54 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:
Substance has been proposed for its inclusion in the Stockholm Convention or a proposal is under preparation in the European Union.

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance has not been registered under the REACH Regulation, therefore as yet ECHA has not received any data about this substance from registration dossiers.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: cosmetics and personal care products, washing & cleaning products and polishes and waxes.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as processing aid.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance can be found in products with material based on: paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper).

This substance is used in the following products: cosmetics and personal care products, washing & cleaning products, polishes and waxes and laboratory chemicals.

This substance is used in the following areas: formulation of mixtures and/or re-packaging and scientific research and development.

This substance is used in the following activities or processes at workplace: non-industrial spraying, roller or brushing applications and hand mixing with intimate contact only with personal protective equipment available.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as processing aid.

This substance is used in the following products: cosmetics and personal care products, leather treatment products, lubricants and greases and textile treatment products and dyes.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, transfer of substance into small containers, industrial spraying, roller or brushing applications, non-industrial spraying, treatment of articles by dipping and pouring and hand mixing with intimate contact only with personal protective equipment available.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: laboratory chemicals and non-metal-surface treatment products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: scientific research and development. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, transfer of substance into small containers, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture and in processing aids at industrial sites.

This substance is used in the following activities or processes at workplace: closed, continuous processes with occasional controlled exposure, transfer of chemicals at dedicated facilities, closed processes with no likelihood of exposure and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: take actions to prevent static discharges; keep away from heat, sparks, open flames and/or hot surfaces – No smoking; use personal protective equipment as required.; avoid release to the environment.

Storage statements

Store this substance in a well-ventilated place and Keeping it cool.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL, Hermeslaan 7 1831 Diegem Belgium
  • 3M Deutschland GmbH, Carl-Schurz-Strasse 1 41453 Neuss Germany
  • AFCONA Additives B.V., Amperestraat 34 1704SN Heerhugowaard Netherlands
  • Chemical Inspection & Regulation Service Limited, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED(HOSHINE SILICON INDUSTRY CO., LTD), Room 002, Regus Harcourt Centre D02 HW77, D02 Dublin Ireland
  • Chemours Netherlands B.V., Baanhoekweg 22 3313 LA Dordrecht Netherlands
  • Chemours Netherlands B.V._1, Baanhoekweg 22 3313 LA Dordrecht Netherlands
  • Chemours Netherlands B.V._2, Baanhoekweg 22 3313 LA Dordrecht Netherlands
  • Chemservice S.A - (C3H9), 13, Fausermillen 6689 Mertert Luxembourg
  • CHT Germany GmbH, Bismarckstr. 102 72072 Tuebingen Germany
  • Clariant Produkte (Deutschland) GmbH, Am Unisys-Park 1 65843 Sulzbach am Taunus Germany
  • Covance Clinical Development SA 023, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 - 5 Planta 28050 Madrid Spain
  • Covestro Deutschland AG, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • COVESTRO S.R.L., Via delle Industrie, 9 24040 Filago (BG) Italy
  • Dow France SAS, 23 Avenue Jules Rimet 93200 La Plaine Saint Denis France
  • Dow Silicones Belgium SPRL OR-1, PSRC - rue Jules Bordet Parc industriel C 7180 Seneffe Belgium
  • Dow Silicones Belgium SPRL OR-2, PSRC - rue Jules Bordet Parc industriel C 7180 Seneffe Belgium
  • Dow Silicones Belgium SPRL OR-3, PSRC - Rue Jules Bordet Zone industrielle C 7180 Seneffe Belgium
  • Dow Silicones UK Limited, PSRC - Cardiff Road CF632YL Barry, South Glamorgan Wales United Kingdom
  • DOW SVERIGE AB, Box 7038 601 17 Norrköping Sweden
  • ELKEM SILICONES FRANCE S.A.S., Immeuble DANICA 21, Avenue Georges Pompidou 69003 Lyon France
  • Evonik Operations GmbH, Rellinghauser Straße 1-11 45128 Essen Germany
  • Intertek Deutschland GmbH CJSS, Stangenstr.1 70771 Leinfelden-Echterdingen Baden-Württemberg Germany
  • KCC Europe GmbH, Hansaring 61 50670 Köln Germany
  • knoell Germany - OR - B19, Konrad-Zuse-Ring 25 68163 Mannheim Germany
  • knoell Germany – OR – B10, Konrad-Zuse-Ring 25 68163 Mannheim Germany
  • knoell Germany – OR – B11, Konrad-Zuse-Ring 25 68163 Mannheim Germany
  • LORD Germany GmbH, Ottostraße 28 41836 Hückelhoven North Rhine - Westphalia Germany
  • Milliken Europe B.V., Ham 18-24 9000 Gent Belgium
  • Momentive Performance Materials GmbH, Chempark Building V7 51368 Leverkusen NRW Germany
  • Rudolf GmbH, Altvaterstr. 58 - 64 82538 Geretsried Germany
  • SABIC Innovative Plastics BV, Plasticslaan 1 4612 PX Bergen op Zoom Netherlands Netherlands
  • Shandong Dongyue Silicon Mat. Co.Ltd. by OR Likedeelers GmbH, Hallbergstr. 10 40239 Düsseldorf NRW Germany
  • Shekoy Chemicals Europe B.V., Kromme Spieringweg 431 2141 AH Vijfhuizen Netherlands
  • Shin-Etsu Silicones Europe BV, Bolderweg 32 1332 AV Almere Netherlands
  • Shin-Etsu Silicones Europe BV - ORT, Bolderweg 32 1332 AV Almere Netherlands
  • Wacker Chemie AG, Hanns-Seidel-Platz 4 81737 Muenchen Germany
  • [Confidential], [Confidential]
  • [Confidential], [Confidential]

Substance names and other identifiers

Cyclic dimethylsiloxane tetramer
D4
Other
Cyclotetrasiloxane, 2,2,4,4,6,6,8,8-octamethyl-
D4
Other
Cyclotetrasiloxane, octamethyl-
D4
Other
KF 994
D4
Other
NUC silicone VS 7207
D4
Other
Octamethylcyclotetrasiloxane
EC Inventory, Candidate list, REACH pre-registration, Other, Cosmetic Products Regulation, Annex II - Prohibited Substances, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Workplace Signs - minimum requirements & signs on containers and pipes, Waste Framework Directive, Annex III - Waste - Hazardous Properties
octamethylcyclotetrasiloxane; [D4]
D4
C&L Inventory
Oktamethylcyklotetrasiloxan
D4
Other
OMCTS
D4
Other
Silicone SF 1173
D4
Other
UC 7207
D4
Other
Union carbide 7207
D4
Other
VS 7207
D4
Other
octamethylcyclotetrasiloxaan; [D4] (nl)
C&L Inventory
octamethylcyclotetrasiloxan; [D4] (da)
C&L Inventory
octametilciclotetrasiloxan; [D4] (ro)
C&L Inventory
Octametilciclotetrasiloxano; [D4] (es)
C&L Inventory
octametilciclotetrassiloxano [D4] (pt)
C&L Inventory
octaméthylcyclotétrasiloxane; [D4] (fr)
C&L Inventory
oktamethylcyklotetrasiloxan; [D4] (cs)
C&L Inventory
oktametilciklotetrasiloksan; [D4] (hr)
C&L Inventory
oktametilciklotetrasiloksanas; [D4] (lt)
C&L Inventory
oktametilciklotetrasiloksāns; [D4] (lv)
C&L Inventory
oktametilciklotetrasziloxán; [D4] (hu)
C&L Inventory
oktametylcyklotetrasiloksan (no)
C&L Inventory
oktametylcyklotetrasiloxan; [D4] (sv)
C&L Inventory
oktametylcyklotetrasiloxán; [D4] (sk)
C&L Inventory
oktametylocyklotetrasiloksan; [D4] (pl)
C&L Inventory
oktametyylisyklotetrasiloksaani; [D4] (fi)
C&L Inventory
Oktametüültsüklotetrasiloksaan; [D4] (et)
C&L Inventory
ottametilciclotetrasilossano; [D4] (it)
C&L Inventory
ottametilċiklotetrasiloksan; [D4] (mt)
C&L Inventory
οκταμεθυλοκυκλοτετρασιλοξάνιο· [D4] (el)
C&L Inventory
октаметилциклотетрасилоксан; [D4] (bg)
C&L Inventory
2,2,2,2,4,4,6,6,8,8-octamethyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane
C&L Inventory
2,2,4,4,6,6,8,8-octamethyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane
C&L Inventory, Registration dossier, Other
2,2,4,4,6,6,8,8-octamethyl-1,3,5,7,2,4,6,8-tetraoxatetrasiloxane
C&L Inventory
2,2,4,4,6,6,8,8-Octamethyl-1,3,5,7,2,4,6,8-tetroxatetrasilocane
C&L Inventory, Registration dossier
2,2,4,4,6,6,8,8-octamethyl-1,3,5,7,2,4,6,8-tetroxatetrasiloxane
Registration dossier
2,2,4,4,6,6,8,8-octamethyl-1,3,5,7-tetraoxy-2,4,6,8-tetrasilacyclooctane
C&L Inventory
cyclosiloxane
Registration dossier
Cyclotetrasiloxane,2,2,4,4,6,6,8,8,-octamethyl-
C&L Inventory
D4
Registration dossier
octamethyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane
Registration dossier, Other
Octamethylcyclotetrasiloxan
C&L Inventory
Octamethylcyclotetrasiloxane, D4
Registration dossier
Octaméthylcyclotetrasiloxane
C&L Inventory
octomethylcyclotetrasiloxane
C&L Inventory
DOW CORNING(R) 244 FLUID
Registration dossier
F-28
Registration dossier
F-42S
Registration dossier
KF-994
Registration dossier
Octame.cy.tetrasil
Registration dossier
SF 1173
Registration dossier
SILBIONE TETRAMERE D4
Registration dossier
T-07V
Registration dossier
T-206
Registration dossier
TETRAMERE D4
Registration dossier
TETRAMERE D4 SP
C&L Inventory
VS-7207
Registration dossier
014-018-00-1
Index number
C&L Inventory
104986-37-0
CAS number
Other
117563-66-3
CAS number
Other
1257661-59-8
CAS number
Other
556-67-2
CAS number
EC Inventory, C&L Inventory, Candidate list, Registration dossier, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Workplace Signs - minimum requirements & signs on containers and pipes, Waste Framework Directive, Annex III - Waste - Hazardous Properties
83874-62-8
CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 1 study submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [1]
C Form
Liquid (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 2 studies submitted
  • 1 study processed
R Melting / freezing point
17.7 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
17.7 °C

Boiling point

Study results
  • 3 studies submitted
  • 1 study processed
R Boiling point
175 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
175 °C

Density

Study results
  • 3 studies submitted
  • 1 study processed
R Relative density
0.95 @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
0.95

Vapour pressure

Study results
  • 6 studies submitted
  • 1 study processed
R Vapour pressure
1.32 hPa @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
1.32 hPa @ 25 °C

Partition coefficient

Study results
  • 5 studies submitted
  • 1 study processed
R Log Pow
6.488 @ 25.1 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
6.49 @ 25.1 °C

Water solubility

Study results
  • 4 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
56.2 µg/L @ 23 °C and pH 7 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
56 µg/L @ 23 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 4 studies submitted
  • 4 studies processed
R Flash point
51 - 61 °C @ 101.3 - 101.325 kPa [5]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 4
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
51 °C

Auto flammability

Study results
  • 2 studies submitted
  • 1 study processed
R Autoflammability / self-ignition
384 - 387 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
384 °C

Flammability

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 3
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Flammable (100%)

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 4 studies submitted
  • 1 study processed
R kinematic viscosity (in mm²/s)
1.6 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Static viscosity at 20 °C
1.6 mm²/s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 3 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
15.8 days
Degradation rate constant with OH radicals
0 cm³ molecule-1 d-1

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life for hydrolysis
93.6 h @ 25 °C

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in freshwater sediment
1 years @ 25 °C

Biodegradation in soil

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in soil
5.25 days @ 20 °C

Bioaccumulation: aquatic / sediment

Study results
  • 20 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 17 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - L/kg ww
14 900 L/kg ww

Bioaccumulation: terrestrial

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
16 596

Henrys law constant (H)

Study results
  • 1 study submitted
  • 1 study processed
R H - (pressure) m³/mol
12 atm m³/mol @ 21.7 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
1 195 640 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 1.5 µg/L (1)
Intermittent releases (freshwater) -
Marine water 150 ng/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 10 mg/L (1)
Sediment (freshwater) 3 mg/kg sediment dw (1)
Sediment (marine water) 300 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 540 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning 41 mg/kg food (1)

Short–term toxicity to fish

Study results
  • 11 studies submitted
  • 1 study processed
P/RResults
LC50 (14 days) 10 µg/L [1]
LC50 (4 days) 22 µg/L [1]
NOEC (14 days) 4.4 µg/L [1]
NOEC (4 days) 22 µg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 10
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (3.1 months) 4.4 µg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 5 studies submitted
  • 1 study processed
P/RResults
EC50 (48 h) 15 µg/L [1]
NOEC (48 h) 15 µg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (21 days) 15 µg/L [1]
LOEC (21 days) 15 µg/L [1]
EC50 (21 days) 15 µg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
EC50 (4 days) 22 µg/L [2]
NOEC (4 days) 22 µg/L [1]
EC10 (4 days) 22 µg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Sediment toxicity

Study results
  • 7 studies submitted
  • 1 study processed
P/RResults
NOEC (28 days) 13 mg/kg sediment dw [1]
LOEC (28 days) 19 mg/kg sediment dw [1]
EC50 (28 days) 32 mg/kg sediment dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 4 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater sediment
13 mg/kg sediment dw

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 73 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: (DNEL) 73 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 13 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: (DNEL) 13 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 3.7 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 23 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1
Supporting study 20 2
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other 1
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential
Absorption values
Oral: 28 %
Dermal: 0.5 %
Inhalation: 8 %

Acute toxicity

Study results
oral
  • 6 studies submitted
  • 1 study processed
P/RResults
LD50 4 800 mg/kg bw (rat) [1]
M/CInterpretations of results
GHS criteria not met [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other 1
Data waiving
no waivers
inhalation
  • 5 studies submitted
  • 1 study processed
P/RResults
LC50 (4 h) 36 mg/L air (rat) [1]
M/CInterpretations of results
GHS criteria not met [1]

inhalation
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 4 studies submitted
  • 1 study processed
P/RResults
LD50 2.5 mL/kg bw (rat) [1]
M/CInterpretations of results
GHS criteria not met [1]

dermal
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed LD50 4 800 mg/kg bw
Inhalation route:
Adverse effect observed LC50 36 000 mg/m³
Dermal route:
No adverse effect observed LD50 2 375 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 7
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Study data: oral
Studies with data
Key study
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 10 studies submitted
  • 1 study processed
P/RResults
NOAEC (rat): 150 ppm [2]

Study data: inhalation
Studies with data
Key study 1
Supporting study 9
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Dermal route - systemic effects:
No adverse effect observed NOAEL 960 mg/kg bw/day (subacute, rabbit)
Inhalation route - systemic effects:
Adverse effect observed NOAEC 1 820 mg/m³ (chronic, rat)
Inhalation route - local effects:
Adverse effect observed NOAEC 1 820 mg/m³ (chronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 11 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 3
Supporting study 8
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Inhalation route:
Adverse effect observed NOAEC 8 492 mg/m³ (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study 6
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: developmental
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 15 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study 15
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Inhalation route:
Adverse effect observed NOAEC 3 640 mg/m³ (subchronic, rat)
Effect on developmental toxicity
Inhalation route:
No adverse effect observed NOAEC 6 066 mg/m³ (subacute, rabbit)

Neurotoxicity

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Study results
  • 13 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 12 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed NOAEL 300 mg/kg bw/day (subacute, rat)
Inhalation route:
No adverse effect observed NOAEC 6 551 mg/m³ (subacute, rat)

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant