Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name: Trimethyl borate
  • IUPAC name: trimethyl borate
  • Other names
EC / List no.:
204-468-9
CAS no.:
121-43-7
Index number:
005-005-00-1
Molecular formula:
C3H9BO3
SMILES:
COB(OC)OC
InChI:
InChI=1S/C3H9BO3/c1-5-4(6-2)7-3/h1-3H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
8
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is a flammable liquid and vapour and is harmful in contact with skin.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is a highly flammable liquid and vapour.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance may damage fertility or the unborn child, causes serious eye irritation and is suspected of damaging fertility or the unborn child.

Breakdown of all 253 C&L notifications submitted to ECHA

Acute Tox. 4 H312 Harmonised Classification
Flam. Liq. 3 H226 Harmonised Classification
Flam. Liq. 2 H225
Repr. 1B H360
Eye Irrit. 2 H319
Repr. 2 H361
Acute Tox. 4 H302
STOT SE 1 H370
STOT RE 1 H372
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 4 active registrations under REACH, 1 Joint Submission(s) and 2 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 100 - 1 000 tonnes per year.

This substance is used by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: welding & soldering products and laboratory chemicals.

This substance is used in the following areas: building & construction work and scientific research and development. This substance is used for the manufacture of: fabricated metal products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, laboratory work, lubrication at high energy conditions and in partly open process, closed processes with no likelihood of exposure and hot work operations with metals (e.g. welding, soldering, gouging, brazing, flame cutting).

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: welding & soldering products, biocides (e.g. disinfectants, pest control products) and plant protection products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, laboratory work and hot work operations with metals (e.g. welding, soldering, gouging, brazing, flame cutting).

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: keep away from heat, sparks, open flames and/or hot surfaces – No smoking; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. In case of fire: Use (measures specified by manufacturer/supplier) for extinction. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.

Storage statements

Store this substance in a well-ventilated place and Keeping it cool.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Ascensus Specialties BVBA, Koningsstraat 97 B-1000 Brussel Brussels Belgium
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • Kemira Chemicals Oy, Harmajantie 3 P.O Box 7 FI-32741 SASTAMALA Finland
  • Klaus F. Meyer GmbH, Leiblstraße 3 67136 Fussgoenheim Germany
  • Vertellus Specialties Belgium NV, Havenlaan 86-C- bus 204 1000 Brussels Belgium
  • Rohm and Haas B.V. deactivated, Valgenweg 7 PO Box 273 9930 AG Delfzijl Netherlands

Other names

  • -
  • Boric acid (h3bo3), trimethyl ester
  • Methyl borate
  • trimethoxyborane
  • Trimethyl Borate
  • Trimethylborate
  • Tromentyl borate
  • Trimethyl borate
  • Trimethyl borate Azeotrope
  • Trimethyl Borate Pure

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 4 studies submitted
  • 3 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [3]
C Form
Other (100%) [2]
C Odour
Other (100%) [1]
C Substance type
Organic (67%), Organometallic (33%) [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Melting/freezing point

Study results
  • 5 studies submitted
  • 3 studies processed
R Melting / freezing point
-31 - -29 °C [5]

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Boiling point

Study results
  • 5 studies submitted
  • 3 studies processed
R Boiling point
67 - 69 °C @ 101.3 - 101.325 kPa [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Density

Study results
  • 9 studies submitted
  • 7 studies processed
R Density
0.91 - 0.915 g/cm³ @ 0 °C [4]
R Relative density
0.915 - 0.933 @ 0 - 25 °C [4]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence 6
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Relative density at 20°C
0.91

Vapour pressure

Study results
  • 5 studies submitted
  • 3 studies processed
R Vapour pressure
18.2 - 235.115 kPa @ 10 - 65 °C [8]

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Partition coefficient

Study results
  • 9 studies submitted
  • 1 study processed
R Log Pow
-0.77 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 4 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Log Kow (Log Pow)
-0.22 @ 25 °C

Water solubility

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 8 studies submitted
  • 3 studies processed
R Flash point
-11 - -6 °C @ 100 - 101.3 kPa [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Auto flammability

Study results
  • 3 studies submitted
  • 2 studies processed
R Autoflammability / self-ignition
303 - 313 °C @ 99.1 - 100.5 kPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flammability

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible 2
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Explosiveness

Study results
  • 3 studies submitted
  • 2 studies processed
C Interpretation of results
Non-explosive (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Half-life for hydrolysis
1.2 s @ 21 °C

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 2 studies submitted
  • 2 studies processed
C Interpretation of results
Readily biodegradable (100%) [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 8
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Study results
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 10
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Adsorption/desorption

Study results
  • 15 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study 6
Weight of evidence 6
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 5.382 mg/L (2)
Intermittent releases (freshwater) 5.382 mg/L (2)
Marine water 5.382 mg/L (2)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 168.18 mg/L (2)
Sediment (freshwater) 7.92 mg/kg sediment dw (2)
Sediment (marine water) 792 µg/kg sediment dw (2)
Hazard for Air
Air -
Hazard for Terrestrial Organism
Soil 1.478 mg/kg soil dw (2)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (2)

Short–term toxicity to fish

Study results
  • 29 studies submitted
  • 4 studies processed
P/RResults
LC50 (4 days) 74 - 15 400 mg/L [4]
EC50 (4 days) 12.7 g/L [2]

Type of Study provided
Studies with data
Key study 4
Supporting study 24
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 29 studies submitted
  • 28 studies processed
P/RResults
NOEC (87 days) 2.1 - 18 mg/L [2]
NOEC (34 days) 5.6 mg/L [8]
NOEC (32 days) 100 - 11 200 µg/L [8]
NOEC (14 days) 86.4 mg/L [2]
NOEC (4 days) 13 mg/L [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 28
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC10 / LC10 or NOEC for freshwater fish
53.82 mg/L

Short–term toxicity to aquatic invertebrates

Study results
  • 55 studies submitted
  • 4 studies processed
P/RResults
EC50 (48 h) 10 g/L [2]
EC50 (24 h) 10 g/L [2]
LC50 (48 h) 133 mg/L [2]
EC0 (48 h) 10 g/L [2]
EC0 (24 h) 10 g/L [2]

Type of Study provided
Studies with data
Key study 4
Supporting study 50
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 25 studies submitted
  • 24 studies processed
P/RResults
NOEC (42 days) 6.6 - 25.9 mg/L [12]
NOEC (28 days) 16.6 - 33.1 mg/L [18]
NOEC (21 days) 6 - 32 mg/L [16]
NOEC (14 days) 2.4 - 18 mg/L [16]
NOEC (12 days) 33.1 mg/L [4]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 24
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 53 studies submitted
  • 14 studies processed
P/RResults
EC50 (4 days) 15.4 - 22 000 mg/L [4]
EC50 (72 h) 40 - 66 mg/L [8]
NOEC (4 days) 10 - 50 mg/L [4]
NOEC (72 h) 17.5 - 27.9 mg/L [8]
LOEC (4 days) 75 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 38
Weight of evidence 12
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Study results
  • 6 studies submitted
  • 6 studies processed
P/RResults
NOEC (3.733 months) 4 mg/L [2]
NOEC (10 days) 6.5 mg/L [2]
NOEC (7 days) 60 mg/L [2]
LOEC (10 days) 3.6 - 19.5 mg/L [4]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 6
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to microorganisms

Study results
  • 17 studies submitted
  • 14 studies processed
P/RResults
EC50 (3 h) 175 mg/L [2]
NOEC (72 h) 10 - 20 mg/L [8]
NOEC (7 h) 100 mg/L [2]
NOEC (3 h) 17.5 - 20 mg/L [4]
LOEC (72 h) 20 - 25 mg/L [6]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 16
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC10 or NOEC for microorganisms
168.18 mg/L

Sediment toxicity

Study results
  • 7 studies submitted
  • 6 studies processed
P/RResults
NOEC (28 days) 37.7 - 180 mg/kg sediment dw [14]
NOEC (28 days) 20 - 43 mg/L [10]
LOEC (28 days) 37.7 mg/kg sediment dw [2]
LOEC (28 days) 40 - 43 mg/L [6]
EC10 (28 days) 40.5 - 42.7 mg/L [4]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 6
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
EC10 / LC10 or NOEC for freshwater sediment
792 mg/kg sediment dw

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 19 studies submitted
  • 12 studies processed
P/RResults
NOEC (63 days) 19.8 - 78.8 mg/kg soil dw [16]
NOEC (56 days) 5.2 - 98 mg/kg soil dw [20]
NOEC (28 days) 174.8 - 315 mg/kg soil dw [8]
EC10 (56 days) 70.1 mg/kg soil dw [2]
EC10 (28 days) 17 - 22.6 mg/kg soil dw [4]

Type of Study provided
Studies with data
Key study
Supporting study 6
Weight of evidence 12
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 11 studies submitted
  • 8 studies processed
P/RResults
NOEC (35 days) 21.9 - 175 mg/kg bw [12]
NOEC (21 days) 174.8 mg/kg soil dw [2]
NOEC (16 days) 98.2 mg/kg soil dw [2]
EC10 (28 days) 13.8 - 68.1 mg/kg bw [8]
EC10 (21 days) 47.5 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence 8
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Long-term EC10 / LC10 / NOEC
148.96 mg/kg soil dw

Toxicity to terrestrial plants

Study results
  • 43 studies submitted
  • 16 studies processed
P/RResults
NOEC (3 months) 10 - 40 mg/kg soil dw [24]
NOEC (70 days) 5 - 10 mg/kg soil dw [4]
NOEC (45 days) 5 - 40 mg/kg soil dw [24]
NOEC (24 days) 16.9 - 42 mg/kg soil dw [6]
NOEC (10 days) 46 - 52 mg/kg soil dw [4]

Type of Study provided
Studies with data
Key study
Supporting study 26
Weight of evidence 16
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 11 studies submitted
  • 6 studies processed
P/RResults
NOEC (28 days) 419.6 mg/kg soil dw [2]
EC10 (3.4 months) 15.4 - 17.2 mg/kg soil dw [4]
EC10 (28 days) 3 - 226 mg/kg soil dw [12]
EC50 (3.4 months) 17.5 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study
Supporting study 4
Weight of evidence 6
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Data not provided by the registrant

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 8.3 mg/m³ developmental toxicity / teratogenicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 392 mg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: No DNEL required: short term exposure controlled by conditions for long-term
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
Medium hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
-

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 36 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 2
Supporting study 18
Weight of evidence 8
Other 8
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation potential:
No bioaccumulation potential

Acute toxicity

Study results
oral
  • 22 studies submitted
  • 4 studies processed
P/RResults
LD50 1 187 - 2 769 mg/kg bw (rat) [4]
M/CInterpretations of results
Not classified [2]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence 1 2
Other 16
Data waiving
no waivers
inhalation
  • 11 studies submitted
  • 4 studies processed
P/RResults
LC50 (6 h) 82.1 - 92.6 mg/L air (rat) [6]
LC50 (4 h) 115.9 - 130.7 mg/L air (rat) [6]

inhalation
Studies with data
Key study
Supporting study
Weight of evidence 4
Other 6
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
dermal
  • 4 studies submitted
  • 2 studies processed
P/RResults
LD50 1 820 mg/kg bw (rabbit) [2]
M/CInterpretations of results
Harmful [2]

dermal
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
other routes
  • 12 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study 12
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2 2
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
Study data: eye
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 2 2
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
Adverse effect observed (irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 43 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Study data: oral
Studies with data
Key study
Supporting study 22
Weight of evidence 2
Other 18
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: inhalation
  • 8 studies submitted
  • 8 studies processed
P/RResults
NOAEC (rat): 6.66 mg/L air [2]
NOAEC (mouse): 1.3 mg/L air [2]
NOAEC (monkey): 13 mg/m³ air [2]
NOEC (rat): 130 mg/m³ air [2]
NOEC (mouse): 130 mg/m³ air [2]

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence 8
Other
Data waiving
no waivers
Study data: dermal
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route - systemic effects:
Adverse effect observed NOAEL 168.18 mg/kg bw/day (chronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 46 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 12
Supporting study 34
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route:
No adverse effect observed NOAEL 1 934 mg/kg bw/day (chronic, mouse)

Toxicity to reproduction

Study results
Study data: reproduction
  • 18 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 4
Supporting study 6
Weight of evidence 4
Other 4
Data waiving
no waivers
Study data: developmental
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 4
Supporting study 10
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study 2
Weight of evidence
Other 6
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Effect on fertility
Oral route:
Adverse effect observed NOAEL 168.18 mg/kg bw/day (chronic, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant