Registration Dossier
Registration Dossier
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EC number: 206-056-4 | CAS number: 298-07-7
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable and sufficient documented
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- skin irritation / corrosion
- Principles of method if other than guideline:
- Saturated cotton swabs were placed on the forearm of six volunteers and the effects were evaluated.
- GLP compliance:
- no
Test material
- Reference substance name:
- Bis(2-ethylhexyl) hydrogen phosphate
- EC Number:
- 206-056-4
- EC Name:
- Bis(2-ethylhexyl) hydrogen phosphate
- Cas Number:
- 298-07-7
- Molecular formula:
- C16H35O4P
- IUPAC Name:
- bis(2-ethylhexyl) hydrogen phosphate
Constituent 1
Method
- Subjects:
- six male volunteers
- Route of exposure:
- dermal
- Reason of exposure:
- intentional, occupational
Results and discussion
- Clinical signs:
- An exposure of 2 to 4 hours revealed no findings, whereas an exposure of 8 hours revealed a moderate erythema and itching.
Any other information on results incl. tables
An exposure of 2 to 4 hours revealed no findings, whereas an exposure of 8 hours revealed a moderate erythema and itching.
Applicant's summary and conclusion
- Conclusions:
- An exposure of 2 to 4 hours revealed no findings, whereas an exposure of 8 hours revealed a moderate erythema and itching.
- Executive summary:
Saturated cotton swabs were placed for 2 - 8 hours by plaster on the skin of the forearm of six volunteers. The forarms of the volunteers were assessed for edema and erytema and other clinical signs.
An exposure of 2 to 4 hours revealed no findings, whereas an exposure of 8 hours revealed a moderate erythema and itching.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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