Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 266-235-8 | CAS number: 66204-44-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2000
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Guideline study (EU A.4) in compliance with GLP. However, the substance is a reaction mixture, and thus probably water, 2-hydroxypropylamine and/or formaldehyde had been measured in the gas phase, and therefore the vapour pressure cannot be attributed to an individual constituent.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Jai Research Foundation
- Type of method:
- static method
- Temp.:
- 25 °C
- Vapour pressure:
- 5.83 hPa
- Remarks on result:
- other: Vapour pressure determined at 30, 40, 50 and 60°C; value for 25°C calculated from regression curve. Probably water, HPA and/or formaldehyde measured.
- Conclusions:
- The vapour pressure analysed according to guideline EU A.4 was 5.83 hPa at 25°C. However, the substance is a reaction mixture, and thus probably water, 2-hydroxypropylamine and/or formaldehyde had been measured in the gas phase, and therefore the vapour pressure cannot be attributed to an individual constituent.
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2001
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Guideline study (EU A.4) in compliance with GLP. However, the substance is a reaction mixture, and thus probably water, 2-hydroxypropylamine and/or formaldehyde had been measured in the gas phase, and therefore the vapour pressure cannot be attributed to an individual constituent.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Siemens AG
- Type of method:
- dynamic method
- Temp.:
- 20 °C
- Vapour pressure:
- 2 hPa
- Remarks on result:
- other: Exothermal decomposition at 180 – 290°C. VP measured in temp. range 50.8 – 86.5°C. Probably water, HPA and/or formaldehyde measured.
- Temp.:
- 25 °C
- Vapour pressure:
- 2.8 hPa
- Remarks on result:
- other: Exothermal decomposition at 180 – 290°C. VP measured in temp. range 50.8 – 86.5°C. Probably water, HPA and/or formaldehyde measured.
- Temp.:
- 50 °C
- Vapour pressure:
- 13.9 hPa
- Remarks on result:
- other: Exothermal decomposition at 180 – 290°C. VP measured in temp. range 50.8 – 86.5°C. Probably water, HPA and/or formaldehyde measured.
- Transition / decomposition:
- yes
- Transition temp.:
- >= 180 - <= 290 °C
- Conclusions:
- The vapour pressure analysed according to guideline EU A.4 was 2.8 hPa at 25°C. However, the substance is a reaction mixture, and thus probably water, 2-hydroxypropylamine and/or formaldehyde had been measured in the gas phase, and therefore the vapour pressure cannot be attributed to an individual constituent.
- Endpoint:
- vapour pressure
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- estimated by calculation
- Adequacy of study:
- other information
- Study period:
- 2005
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Remarks:
- Generally accepted calculation method
- Temp.:
- 25 °C
- Vapour pressure:
- 0.014 hPa
- Remarks on result:
- other: Value for 25 °C calculated with Epi Suite 3.12, MPBPWIN v1.41.
- Temp.:
- 20 °C
- Vapour pressure:
- 0.01 hPa
- Remarks on result:
- other: Value for 20 °C estimated with EUSES (Generally accepted model calculation)
- Conclusions:
- The vapour pressure calculated with MPBPWIN v1.41 (Epi Suite) resulted in a value of 0.014 hPa at 25°C .
Referenceopen allclose all
Description of key information
The vapour pressure calculated with MPBPWIN v1.41 (Epi Suite) resulted in a value of 0.014 hPa at 25°C . The vapour pressure was determined experimentally by two studies according to guideline EU A.4 resulting in 5.83 hPa (Schülke & Mayr) and 2.8 hPa (Bode) at 25°C.
Key value for chemical safety assessment
- Vapour pressure:
- 0.014 hPa
- at the temperature of:
- 25 °C
Additional information
The vapour pressure of the substance was determined experimentally by two studies, resulting in 5.83 hPa and 2.8 hPa at 25°C. However,the substance is a reaction mixture. Thus, probably water, 2-hydroxypropylamine and/or formaldehyde had been measured in the gas phase, and therefore the vapour pressure cannot be attributed to an individual constituent. In contrast to the experimental results, the calculated value for the main constituent 3,3’-methylene-bis[5-methyl-oxazolidine] (0.014 hPa at 25°C) is lower by several orders of magnitude. For exposure calculations, the calculated value of the main constituent is used as the most appropriate estimation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.