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Ecotoxicological information

Long-term toxicity to fish

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Administrative data

Endpoint:
fish, juvenile growth test
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Aquatic ECETOC database
Cross-reference
Reason / purpose:
read-across source
Reference
Endpoint:
fish, juvenile growth test
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Study period:
September 2016
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: read across from supporting analogue
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH

1. HYPOTHESIS FOR THE ANALOGUE APPROACH
The hypothesis of this analogue approach is based on common functional groups (the target substance and the source substance are both phenols under "US-EPA New Chemical Categories"), and based on additional subcategorization on common end-point specific profiling (based on "Aquatic toxicity classification by ECOSAR") and high structural similarity (60-70% based on Dice (Atom centered fragment)).
Additional refinement was performed on the test conditions from the analogue.

2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Source chemical: 2,4 dimethylphenol CAS 105-67-9
Target chemical: 2,4,6-trimethylphenol CAS 527-60-6

3. ANALOGUE APPROACH JUSTIFICATION
Please refer to the attached report generated by OECD QSAR Toolbox v.3.4

4. DATA MATRIX
Please refer to the attached report generated by OECD QSAR Toolbox v.3.4
Reason / purpose:
read-across: supporting information
Qualifier:
according to
Guideline:
other: ECHA Guidance R.6
Key result
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
2.23 mg/L
Remarks on result:
other: predicted NOEC from read across approach
Validity criteria fulfilled:
not applicable
Conclusions:
The predicted NOEC on growth rate from 28 days long term toxicity test on Pimephales promelas is 2.23 mg/L (based on read across approach from structural analogue).

Data source

Reference
Reference Type:
publication
Title:
Effects of phenol, 2,4-dimethylphenol, 2,4-dichlorophenol, and pentachlorophenol on embryo, larval, and early-juvenile fathead minnows (Pimephales promelas)
Author:
Gary W. HolcombeGary L. PhippsJames T. Fiandt
Year:
1982
Bibliographic source:
Arch Environ Contam Toxicol 11:73

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test organisms

Test organisms (species):
Pimephales promelas

Results and discussion

Effect concentrations
Key result
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
2 mg/L
Conc. based on:
test mat.
Basis for effect:
growth rate

Applicant's summary and conclusion

Conclusions:
Based on the data available from ECETOC database, the NOEC on growth rate from a 28-days as described in the publication "Effects of phenol, 2,4-dimethylphenol, 2,4-dichlorophenol, and pentachlorophenol on embryo, larval, and early-juvenile fathead minnows (Pimephales promelas)" is 2.0 mg/L.
This result was used as source chemical data for a read across approach.