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EC number: 690-796-1 | CAS number: 420-16-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
No study data is available for the test substance. Similar to all coordination complexes of boron trifluoride with organic and inorganic species (like alcohols, ethers, amines, sulfuric acid, sulfuric dioxide, etc) the complex of boron trifluoride and acetonitrile is extremely water sensitive and reacts even with moist air. In the instantaneous reaction with water as a first step acetonitrile and boron trifluoride dihydrates are formed. The latter undergoes further rapid hydrolysis to boric acid, fluoboric acid and tetrafluoroborate. Therefore aquatic toxicity was assessed with adequate raed-across substances like boric acid and acetonitrile. The most reliable acute fish tests with boric acid (4-day duration) showed mortality effects (LC50) in the range of 125 to 600 mg B/L and were performed in salmonids (Oncorhynchus kisutch, O. tshawtscha) and several endangered species (Gila elegans, Ptychocheilus lucia, Xyrauchen texanus, and Catostomas latipinnis). A study performed with ammonium tetrafluoroborate resulted in a LC50 of 600 mg substance/L. A further study was performed with acetonitrile in Pimephales promelas and the LC50 (96h) was 1640 mg/L.
key (publications; boric acid)
The purpose of the study conducted by Hamilton and Buhl (1997) was to determine the acute toxicity of arsenate, boron, copper, molybdenum, selenate, selenite, uranium, vanadium, and zinc singly, and of five environmental inorganic mixtures to larval flannelmouth sucker in water simulating the San Juan River. The tests were performed according the following national standards:
- ASTM (1989). Standard guide for conducting acute toxicity tests with fish; macroinvertebrates, and amphibians.
- APHA, AWWA, WPCF (1989). Standard Methods for the Examination of Water and Wastewater
The acute toxicity values of the different test substances were then compared with environmental concentrations of their inorganics found in various waters in the San Juan River to assess their potential hazard to flannelmouth sucker.
Groups of 10 fish were exposed to a geometric series of six to eight nominal concentrations of boric acid (CAS No 10043-35-3) and a control treatment under static conditions. The acute toxicity value for boron for flannelmouth sucker was estimated at 125 mg B/L and was on the lower end of the wide range reported in the published literature.
In another publication Hamilton (1995) reported 96 h LC50s for boron of 233 mg/L for razorback sucker and 279 mg/L for Colorado squawfish, both tested in reconstituted Green River water. Others have reported LC50 values for boron within this range that encompass those in the present study (Tumbull et al.,1954; Taylor et al.,1985; Hamilton and Buhl, 1990). The wide range of values reported may be due in part to the different boron compounds and fish species tested and to the dilution water used.
supporting (public references 1954 -1998; focus on boron)
A few studies reported endpoints in the 5 to 15 mg B/L range, but these were judged not reliable, or did not have sufficient information to permit data quality review. For example, Turnbull et al. (1954) reported a 24-hour median tolerance limit (TLm) to bluegill of 4.6 mg B/L in response to the read across substance sodium tetraborate decahydrate (CAS No 1303-96-4). However, they also reported a 24-hour TLm of 2389 mg B/L in response to the read across substance boron trifluoride (CAS No 7637-07-2).
Their procedure used relatively large fish (ca. 5 g, 7 cm). No information was provided on replication, intervals between test concentrations, or similar operational details. Guhl (1992a) reported 96-hour LC50 for zebrafish of 14.2 mg B/L, but cited an unpublished study from Henkel KGaA. Terhaar et al. (1976) reported median lethal times for boric acid (CAS No 10043-35-3) of 10 hours, exposed to 1750 mg B/L which was extrapolated to an acute toxicity estimate of 17.5 to 175 mg B/L. These studies cannot be adequately reviewed or compared to standard protocols, thus they cannot be judged reliable. This compilation of public references also include more reliable LC50 values of about 600 mg B/L in Oncorhynchus kisutch and O. tshawtscha.
supporting (publication; ammonium tetrafluoroborate)
Static 96-hr toxicity tests were conducted with 40 such chemicals to provide basic toxicity data for regulatory decision making (Curtis and Ward, 1981). Thirty-two of the 40 chemicals tested were hazardous to aquatic life as determined by 96-hr LC50 values less than or equal to 500 mg/L. All 40 chemicals were tested with the fresh water fathead minnow (Pimephales promelas). With regards to the read across substance ammonium tetrafluoroborate (EC No 237-531-4) no mortality was observed below 600 mg/L.
supporting (publication; acetonitrile)
An acute toxicity study was performed with acetonitrile (CAS no. 75-05-8; Brooke et al., 1984). The test item was tested with fathead minnow (Pimephales promelas). The LC50 (96h) was 1640 mg/L.
Conclusion:
Considering the reliable LC50 values as a worst case result the
acute toxicity value for boron for flannelmouth sucker at 125 mg B/L can
be applied to the reference substance boron trifluoride acetonitrile.
All reliable LC50 values (for boron, ammonium tetrafluoroborate, and
acetonitrile) are above 100 mg/L.
Thus, based on the results of the acute ecotoxicity tests in fish no
classification and labelling is triggered.
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