Registration Dossier
Registration Dossier
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EC number: 203-804-1 | CAS number: 110-80-5
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: NIOSH report
- Title:
- Reproductive Effects of Glycol Ethers in Females -- A Quantitative Analysis
- Author:
- Ballew, M. and Hattis, D.
- Year:
- 1 989
- Bibliographic source:
- NTIS Report No. PB 129222
Materials and methods
- GLP compliance:
- not specified
- Type of method:
- other: risk estimation
Test material
- Reference substance name:
- 2-ethoxyethanol
- EC Number:
- 203-804-1
- EC Name:
- 2-ethoxyethanol
- Cas Number:
- 110-80-5
- Molecular formula:
- C4H10O2
- IUPAC Name:
- 2-ethoxyethan-1-ol
- Details on test material:
- Name of the test substance as stated in the publication: Ethylene glycol monoethyl ether
Constituent 1
Results and discussion
Any other information on results incl. tables
| Reproductive effect | Projected reproductive risk frequency for effect | Doses (ppm 2 -ethoxyethanol) projected to be associated with the risk* | |
| Lower limit | Best estimate | ||
| Miscarriages | 10^(-6) | 0.00056 | 0.53 |
| 10^(-4) | 0.0061 | 1.8 | |
| Minor skeletal defects | 10^(-6) | 4.4 x 10^(-6) | 0.022 |
| 10^(-4) | 4.8 x 10^(-5) | 0.073 | |
| External malformations | 10^(-6) | 0.0011 | 1.1 |
| 10^(-4) | 0.012 | 3.5 | |
| Digit or limb malformations | 10^(-6) | - | - |
| 10^(-4) | - | - | |
| Total malformations | 10^(-6) | - | - |
| 10^(-4) | - | - | |
| Infant mortality (projected from fetal weight changes) | 10^(-6) | - | 0.069 |
| 10^(-4) | - | 6.8 | |
* Values in the lower limit column represent the doses associated with the indicated level of effect under a more pessimistic assumption about the degree of interindividual variability in susceptibility of the human population (log probit slop 1). Values in the best estimate column represent calculations using the investigators' "best-estimate" assumption of the degree of interindividual variability in susceptibility for the quantal effects (log probit slop 2).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
