Registration Dossier
Registration Dossier
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EC number: 203-804-1 | CAS number: 110-80-5
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on developmental toxicity
Description of key information
The lowest NOAEL was determined in the rat with a value of 25 µL/kg/day (23 mg/kg/day with a density of 0.919 g/mL at 25 °C). The doses were administered orally during gestation (key data from Stenger 1971).
For the chemical safety assessment of inhalation exposure a LOAEC derived from a subacute inhalative toxicity study (daily 6 hours during gestation, 10 ppm corresponding to 37.4 mg/m³) in rat (Doe et al. 1984, key study for developmental toxicity, see Endpoint record 7.8.2.001) was used.
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 23 mg/kg bw/day
Effect on developmental toxicity: via inhalation route
- Dose descriptor:
- LOAEC
- 37.4 mg/m³
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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