2,3-epoxypropyl phenyl ether

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

Not reported

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Although this pre-dates international guidelines for acute inhalation toxicity studies and GLP, in accordance with REACH Annex XI, Section 1.1.2, the study was conducted under sound scientific principles of acute toxicity studies. The study is therefore considered adequate for contributing evidence towards this endpoint in a weight of evidence approach.

Data source

Reference

Reference Type:

publication

Title:

The toxicology of glycidol and some glycidyl ethers

Author:

C. H. Hine

Year:

1956

Bibliographic source:

Hine, C.H., Kodama, J.K., Wellington, J.S., Dunlap, M.K. and Anderson, H.H. (1956) The toxicology of glycidol and some glycidyl ethers. Archives of Industrial Health, 14: 250-264.

Materials and methods

Principles of method if other than guideline:

Male Long-Evans rats were exposed to a single dose phenylglycidyl ether vapours for 8 hours and the observation period was 10 days.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2,3-epoxypropyl phenyl ether

EC Number:

204-557-2

EC Name:

2,3-epoxypropyl phenyl ether

Cas Number:

122-60-1

Molecular formula:

C9H10O2

IUPAC Name:

2-(phenoxymethyl)oxirane

Test animals

Species:

rat

Strain:

Long-Evans

Sex:

male

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

not specified

Vehicle:

air

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

8 h

No. of animals per sex per dose:

6 male rats per group.

Control animals:

not specified

Results and discussion

Effect levels

Effect levels 1

Sex:

male

Dose descriptor:

LC50

Effect level:

> 100 ppm

Based on:

test mat.

Exp. duration:

8 h

Effect levels 2

Sex:

male

Dose descriptor:

LC50

Effect level:

> 200 ppm

Based on:

test mat.

Exp. duration:

4 h

Remarks on result:

other: Experimental LC50 (100 ppm) for 8 hour exposure was modified to 4 h using Haber's Law (C1t1=C2t2)

Clinical signs:

other: Dyspnoea, watering eyes, salivation, rhinitis and aerophagy were observed in the animals. At post-mortem, marked irritation of the lung accompanied by acute interstitial pneumonia was seen. This was confirmed by histological examination.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The 4h acute inhalation LC50 of phenylglycidyl ether to rats was estimated as >200 ppm.