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EC number: 932-389-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- November 1980 - December 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- This study was conducted with a method equivalent to the OECD 414 (2001): OPPTS 870.3700 (1998): 2004/73/EC B.31 (2004) Guidelines and following the principlesand practices of Good laboratory Practice. A Quality Assurance statement is included in the report. None of the deviations from the current regulatory guideline are considered to compromise the scientific validity of the study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 870.3700 (Prenatal Developmental Toxicity Study)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.31 (Prenatal Developmental Toxicity Study)
- Principles of method if other than guideline:
- The following deviations from current guidelines were noted:
The volume administered was 10 ml/kg in maize oil (the current guideline states that when corn oil is used as a vehicle, the volume should not exceed 0.4 ml/100 g bodyweight).
The test substance was not administered daily from pre-implantation (e.g. day 5 post mating) until the day prior to scheduled caesarean section.
Two-thirds of each litter (rather than half) were processed for skeletal examination and one-third for soft tissue examination.
These deviations from the current regulatory guideline are considered not to compromise the scientific validity of the study. - GLP compliance:
- yes
Test material
- Reference substance name:
- Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate
- EC Number:
- 932-389-6
- Molecular formula:
- C23H19ClF3NO3
- IUPAC Name:
- Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate
Constituent 1
Results and discussion
Results (fetuses)
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The study is considered to be reliable with restrictions. The results are sufficiently detailed and unambiguous as to be adequate for risk assessment, classification and labeling.
- Executive summary:
Groups of 24 sexually mature mated female rats receivedcyhalothrin by gavage at dosages of 5, 10 or 15 mg/kg body weight daily for 10 consecutive days, from day 6 to 15 of gestation. Agroup of similar rats which received maize oil (the vehicle) over the same period served as the control group. The animals were killed on day 20 of gestation.
Clinical condition, body weight, food intake, pregnancy incidence and the outcome of gestation were assessed.
There were no mortalities in the control or cyhalothrintreated groups.
Two animals given 15 mg/kg/day cyhalothrin showed loss of limb co-ordination. This change in behaviour, although of very low incidence in this study, has previously been attributed to treatment with cyhalothrin at higher dosages. Otherwise there were no changes in clinical condition attributableto treatment with cyhalothrin and no macroscopic changes were observed at necropsy.
The initial effect of treatment with cyhalothrin on maternal body weight was dosage-related, with weight loss being observed in all groups. Treatment with cyhalothrin at 15 mg/kg/day was associated with an overall significant reduction of body weight gain. However, the rate of weight gain from day 7 was generally comparable with the control group. Only marginal reductions in body weight gain were recorded at 5 and 10 mg/kg/day cyhalothrin.
Treatment with cyhalothrin at 15 mg/kg/day was alsoassociated with reduced food intake throughout the study, thedifference from the controls being significant between days 6 and12 of gestation. At 5 and 10 mg/kg/day cyhalothrin, only slightreductions in food intake were apparent during the study.
There was no effect of treatment with cyhalothrin on pregnancy incidence.
There was no effect of treatment with cyhalothrin oncaesarean parameters on day 20 of pregnancy as assessed by the number, size, weight and sex of the foetuses and by pre and post-implantation losses. Further, gravid uterus weights were comparable in all groups.
There was no effect of treatment with cyhalothrin on theincidence of major defects, minor external and visceral defects orminor skeletal defects and variants.
Administration of cyhalothrin at 15 mg/kg/day by the oral route during days 6 to 15 of gestation elicited maternal toxicity. However, there was no effect of treatment at 5, 10 or 15 mg/kg/day on any aspect of foetal development. The maternal toxicity NOAEL is 10 mg/kg/day and the developmental toxicity NOAEL is > 15 mg/kg/day.
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