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Diss Factsheets
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EC number: 932-389-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Insignificant route of exposure.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Five male rats per dose group were exposed to cyhalothrin in corn oil by intraperitoneal (i.p.) injection. Animals were observed for signs of intoxication daily up to 14 days.
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate
- EC Number:
- 932-389-6
- Molecular formula:
- C23H19ClF3NO3
- IUPAC Name:
- Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Alderley Park SPF-derived albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Animal Breeding Unit, ICI Ltd., Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire, UK
- Weight at study initiation: 119-220 g
- Fasting period before study: 16-20 h
- Housing: in stainless steel cages with a maximum of 5 animals per cage
- Diet (e.g. ad libitum): BP PCD pellets ad libitum
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period: at least 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-23°C
- Humidity (%): 50-60%
- Air changes (per hr): 24
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- corn oil
- Details on exposure:
- Volume applied: 10 mL/kg bw
- Doses:
- 50, 250, 500, 750, and 1000 mg/kg bw
- No. of animals per sex per dose:
- 5 males per dose group were used.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 250 - < 750 mg/kg bw
- Based on:
- test mat.
- Mortality:
- In the 50 and 250 mg/kg bw dose groups no animal died. One animal died following a dose of 500 mg/kg bw. In the 750 mg/kg bw dose group, 2 animals were found dead and the remainder was terminated in extremis by day 4. All animals died in the 1000 mg/kg bw dose group.
- Clinical signs:
- Clinical signs included incontinence, scouring, subdued behaviour, piloerection, damp fur, tip-toe gait, hyperactivity, hypersensitivity to noise, ungroomed appearance, and at higher concentrations lacrimation, dehydration, ataxia, upward curvature of the spine, slow righting reflex, laboured respiration, hypothermia, and convulsions.
Applicant's summary and conclusion
- Conclusions:
- The study is not reliable because insignificant route of exposure.
- Executive summary:
Acute toxicity of cyhalothrin to rats was determined by intraperitoneal application to 5 male animals per dose group at 50, 250, 500, 750, and 1000 mg/kg bw. Mortality and clinical signs were monitored daily for a period of 2 weeks. GLP compliance was stated.
Mortality in the 50, 250, 500, 750, and 1000 mg/kg bw groups was 0, 0, 1, 5, and 5 of five animals, respectively.
The LD50 of cyhalothrin after i.p. administration to male rats was therefore estimated to be in the range 250-750 mg/kg bw.
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