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Diss Factsheets
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EC number: 932-389-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LD50 (rat, oral)=166 mg/kg bw in males and 114 mg/kg bw in females (Pritchard, 1984)
LD0 (rat, dermal) =200 mg/kg bw in female rats, LD0 (rat, dermal)=1000 mg/kg bw in male rats (Nixon, 1981)
LD50 (rabbit, dermal) > 2 mL/kg bw in both sexes (Nixon, 1981)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 114 mg/kg bw
Additional information
Four studies reports are available for the determination of the acute oral toxicity.
Only one study (Pritchard, 1984) has been considered reliable (with minor restrictions) and adequate for the purposes of risk assessment, classification and labeling.
The study conducted on rats (Nixon, 1981) has been considered as supporting study and both the studies on mouse (Nixon, 1981) and guinea pig (Nixon, 1981) have been considered as disregarded studies based on Klimisch rating and because adequate data in the rat is available.
Four studies reports are available for the determination of the acute dermal toxicity.
All the studies have been considered for their reliability, and while on a formal rating may be evaluated to have deviations and therefore be of low reliability, taken into consideration together they do provide a comprehensive weight of evidence.
A weight of evidence approach was taken therefore and the LD50 >200 mg/kg bw (where LD0=200 mg/kg bw in female rats) has been chosen as conservative “worst case value” for the purposes of risk assessment, classification and labeling.
No data on acute inhalation toxicity.
A study on acute toxicity to rats determined by intraperitoneal application (Nixon, 1981) is cited but considered not reliable because insignificant route of exposure.
Justification for classification or non-classification
Based upon the classification criteria according to the Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008, the test item has to be classified as Toxic Category III for acute oral and dermal route.
The value for the acute oral toxicity, LD50=114 mg/kg bw does lead to the classification of the substance as R25, Toxic if swallowed, according to the criteria in Directive 2001/59/EC, Annex VI, 3.2.
The value for the acute dermal toxicity in female rat, LD50>200 mg/kg bw does lead to the classification of the substance as R24, Toxic in contact with skin according to the criteria in Directive 2001/59/EC, Annex VI, 3.2.
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