Registration Dossier
Registration Dossier
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EC number: 203-801-5 | CAS number: 110-76-9
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- 06. Jun 1978 - 28. jun 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable well documented report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- BASF-Test
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-ethoxyethylamine
- EC Number:
- 203-801-5
- EC Name:
- 2-ethoxyethylamine
- Cas Number:
- 110-76-9
- Molecular formula:
- C4H11NO
- IUPAC Name:
- 2-ethoxyethylamine
- Details on test material:
- - Name of test material (as cited in study report): 2-Aethoxyaethylamin
- Analytical purity: 98 %
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: male: 26 g (mean), female: 24 g (mean)
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- 50, 200 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Frequency of weighing: days 0, 2, 7, 13
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 50 - 200 mg/kg bw
- Mortality:
- see details in remarks on results.
- Clinical signs:
- 200 mg/kg bw:
within 15 min of application: dyspnoea, apathy, ruffled fur, spastic gait.
5 h post application: abdominal position, atony, narcotic condition.
2 days post application: exsiccosis.
50 mg/kg bw: no abnormalities. - Body weight:
- In the 50 mg/kg bw dose group the animals gained weight.
- Gross pathology:
- 200 mg/kg bw: no substance related abnormalities in animals that died during the first 24 h. Later on dying animals were cadaveric
50 mg/kg bw: weak gastric bleeding
Any other information on results incl. tables
Mortality:
| Dose (mg/kg) | Gender | dead within 1h | dead within 1 day | dead within 2 days | dead within 7 days | dead within 14 days | |
| 50 | male | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | |
| female | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | ||
| 200 | male | 0/5 | 3/5 | 4/5 | 5/5 | 5/5 | |
| female | 0/5 | 5/5 | 5/5 | 5/5 | 5/5 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
