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Diss Factsheets
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EC number: 203-801-5 | CAS number: 110-76-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03. May 1978 - 12. Jun 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable well documented report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- BASF-Test: A test group consisting of 5 animals/sex was treated by single dermal application of the test substance. Twenty-four hours prior the dermal applications, the backs of the rabbits were shaved free of hair with electric clippers. On the testing day, the dermal applications (1000 or 2000 mg/kg bw) of the test material were made in undiluted form on the exposure sites (ca. 42 cm2) of the rats. After application, the exposure site was covered by wrapping the trunk of the animal with an aluminium foil which was securely taped in place. The test material remained in contact with the skin for 24 hours. After the application time the skin was washed with water/Lutrol (1:1). Observations for mortality, local reactions, and behavioral abnormalities were continued for a total of 14 days following the skin applications.
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- 2-ethoxyethylamine
- EC Number:
- 203-801-5
- EC Name:
- 2-ethoxyethylamine
- Cas Number:
- 110-76-9
- Molecular formula:
- C4H11NO
- IUPAC Name:
- 2-ethoxyethylamine
- Details on test material:
- - Name of test material (as cited in study report): 2-Aethxoyaethylamin
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: male: 204 g (mean), female: 208 g (mean)
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- no data
- Doses:
- 1000, 2000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 000 - 2 000 mg/kg bw
- Mortality:
- 1000 mg/kg bw: no mortalities occured.
2000 mg/kg bw: 3/3 males and 2/3 females died within 24 h. - Clinical signs:
- other: 2000 mg/kg bw: irregular respiration, apathy, spastic gait
- Gross pathology:
- 2000 mg/kg bw: heart: dilatation on the right ventricle, congestion; liver coloured as clay.
Sacrificed animals: no abnormalities observed.
Any other information on results incl. tables
Of moderate toxicicty after a short term skin contact.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.