2-Propenoic acid, 2-propylheptyl ester

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Study period:

1958-11-07

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study with acceptable restrictions (no analytical monitoring of test atmosphere concentration). Read across was performed with 2-ethylhexyl acrylate. Please refer to IUCLID section 13 for read across justification.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1958

Report date:

1958

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Version / remarks:

(adopted 1981)

Deviations:

yes

Remarks:

no analytical monitoring of the test atmosphere concentration

Principles of method if other than guideline:

BASF Test
This test (also called inhalation hazard test) was performed in principle as described in OECD Guideline 403. It demonstrates the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance at the temperature chosen for vapor generation (20 °C and 1002.6 hPa).
Several groups of 3 rats per sex were exposed sequentially to the vapors, generated by bubbling 200 L/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder containing approximately 120 mL test substance for 8 hours. Compressed air without further filtering was used in order to generate the test substance atmosphere. No analytical determination of the atmosphere concentrations was performed. The nominal concentration was calculated as quotient of the amount of test substance weight loss during the exposure, which was given in the raw data, and the amount of air used during the exposure. Group-wise documentation of clinical signs was performed over the 14-day study period. Body weight of groups was determined before the start of the study and at the end of the observation period in the surviving animals. The clinical signs and findings were reported in summarized form. The study allows for an estimate of the length of time required to cause severe toxic effects resulting from exposure to an atmosphere saturated with volatile components of the test substance.

GLP compliance:

no

Test type:

other: Inhalation hazard test

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2-ethylhexyl acrylate

EC Number:

203-080-7

EC Name:

2-ethylhexyl acrylate

Cas Number:

103-11-7

IUPAC Name:

2-ethylhexyl acrylate

Test material form:

other: liquid

Details on test material:

- Test substance: 2-ethylhexyl acrylate
- Chemical name: 2-propenoic acid, 2-ethylhexyl ester
- Impurities: stabilised with 0.05 % hydrochinone
- Density: 0.887 g/cm3 (DIN 51757, cited in EU RAR, 2005)

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 884 g (mean)

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

1.19 mg/L

No. of animals per sex per dose:

3

Control animals:

no

Details on study design:

The vapour saturation was calculated based on the vapour pressure at 25 °C and the molecular weight.
Vapour saturation = 1.82 mg/L at 25 °C.
The assumed vapour saturation at the test temperature of 20 °C would be slightly lower than the calculated value but still greater than 1 mg/L. Thus, it can be safely concluded that the animals in the present study were indeed exposed to test substance vapours and no aerosol.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

1.19 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

8 h

Remarks on result:

other: No mortality observed at a satuated atmosphere with volatile parts of the component

Mortality:

No mortality was observed when 6 rats were exposed for 8 hours to an atmosphere that had been saturated at 20°C with the volatile parts of the compound.

Clinical signs:

other: No clinical signs were noted during the test.

Body weight:

Body weights increased continuously.

Gross pathology:

Since the test animals showed neither clinical signs nor other abnormalities, the necropsy was omitted.