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Diss Factsheets

Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Acute Toxicity, Eye Irritation, Primary Skin Irritation, Skin Sensitization, Phototoxicity, Photosensitization, Mutagenicity of Polyoxypropylene (12) [(2‘-0-β-D-glucopyranosyl-β-D-glucopyranosyl) oxy-] fatty acid ester
Author:
Ikeda Y. et al.
Year:
1986
Bibliographic source:
The Journal of Toxicological Sciences Vol.11, 197-211

Materials and methods

Test material

Constituent 1
Reference substance name:
Polyoxypropylene (12) [2'-0-beta-D-glucopyranosyl-beta-D-glucopyranosyl) oxy-] fatty acid ester-]
IUPAC Name:
Polyoxypropylene (12) [2'-0-beta-D-glucopyranosyl-beta-D-glucopyranosyl) oxy-] fatty acid ester-]

In vivo test system

Test animals

Species:
guinea pig
Strain:
Hartley

Results and discussion

In vivo (non-LLNA)

Resultsopen allclose all
Reading:
other: open challenge
Hours after challenge:
24
Group:
test chemical
Dose level:
10 and 50%
No. with + reactions:
0
Total no. in group:
15
Remarks on result:
no indication of skin sensitisation
Reading:
other: open challenge
Hours after challenge:
48
Group:
test chemical
Dose level:
10 and 50%
No. with + reactions:
0
Total no. in group:
15
Remarks on result:
no indication of skin sensitisation
Reading:
other: open challenge
Hours after challenge:
72
Group:
test chemical
Dose level:
10 and 50%
No. with + reactions:
0
Total no. in group:
15
Remarks on result:
no indication of skin sensitisation
Reading:
other: occlusive (24 hours) challenge
Hours after challenge:
24
Group:
test chemical
Dose level:
50%
No. with + reactions:
0
Total no. in group:
15
Remarks on result:
no indication of skin sensitisation
Reading:
other: occlusive (24 hours) challenge
Hours after challenge:
48
Group:
test chemical
Dose level:
50%
No. with + reactions:
0
Total no. in group:
15
Remarks on result:
no indication of skin sensitisation
Reading:
other: occlusive (24 hours) challenge
Hours after challenge:
72
Group:
test chemical
Dose level:
50%
No. with + reactions:
0
Total no. in group:
15
Remarks on result:
no indication of skin sensitisation

Any other information on results incl. tables

No sensitising reaction was observed in either the open nor the 24-hour closed application.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
No sensitising reaction was observed in a GPMT in either the open or the 24-hour closed application of the test material for Sophorolipid (C16-C18).
Executive summary:

In a GPMT according to Magnusson and Kligman (1969), Sophorolipid (C16-18) did not show a sensitising reaction in either the open or the 24-hour closed application.