Registration Dossier
Registration Dossier
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EC number: 610-472-5 | CAS number: 49707-23-5
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010-01-22 to 2010-05-07
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to recent OECD technical guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- N-(2,2-dimethoxyethyl)prop-2-enamide
- EC Number:
- 610-472-5
- Cas Number:
- 49707-23-5
- Molecular formula:
- C7 H13 N1 O3
- IUPAC Name:
- N-(2,2-dimethoxyethyl)prop-2-enamide
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- 522 g/L
- Temp.:
- 20 °C
- pH:
- > 7.2 - < 7.3
- Details on results:
- See section "Any other information on results incl. tables".
Any other information on results incl. tables
Method:
The water solubility of the test item was determined using the shake flask method. The saturation mass concentration of the test itemwas determined using a HPLC method.
Result of the Preliminary Test (non-GLP):
The test item was found miscible with water. Thus a ratio of 1:1 test item to water was used for the main test.
Result of the Main Test:
The concentration of the test item was measured using an HPLC method. The linearity of the analytical method was proven in the concentration range from 10 to 300 mg test item/L. The regression coefficient was determined to be 0.9999.
No differences higher than 4 % were found between samples. Therefore, the study is considered to be valid.
The test item was found completely miscible with water. Corresponding to the analysis the water solubility of the test item was calculated to be 522 g/L at 20 °C.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): miscible
The test item was found completely miscible with water. Corresponding to the analysis the water solubility of the test item was calculated to be 522 g/L at 20 °C.
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