Registration Dossier
Registration Dossier
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EC number: 203-464-4 | CAS number: 107-12-0
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Remarks:
- intraperitoneal injection
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- publication
- Title:
- The role of cyanide liberation in the acute toxicity of aliphatic nitriles
- Author:
- Willhite, Calvin C.
Smith, Roger P. - Year:
- 1 981
- Bibliographic source:
- Willhite, C.C. & Smith, R.P., 1981. The role of cyanide liberation in the acute toxicity of aliphatic nitriles. Toxicology and Applied Pharmacology, 59(3), pp.589–602.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The toxicity of propionitriel to mice was determined using intraperitoneal injection..
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Propiononitrile
- EC Number:
- 203-464-4
- EC Name:
- Propiononitrile
- Cas Number:
- 107-12-0
- Molecular formula:
- C3H5N
- IUPAC Name:
- propanenitrile
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Male CD-1 mice (30 g) were maintained on tap water and laboratory chow ad libitum.
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- Five geometrically spaced doses of propionitrile wer administered ip to groups of nine or ten mice: 20-50 mg/kg.
- No. of animals per sex per dose:
- 10
- Details on study design:
- All injected solutions were adjusted to volumes of 1 ml / 100 g body weight. The animals were observed for the following 7 days in all mortality experiments. The approximate time of death was recorded and the LD50 was calculated.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 28 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 25 - <= 31
- Mortality:
- Mean time until death: 1260 +- 1518 (SD) min
Applicant's summary and conclusion
- Conclusions:
- The toxicity of proprionitrile to mice was tested via intraperitoneal injection at concentrations of 20-50 mg/kg bw. High mortality was observed and an LD50 of 28 (25-31) mg/kg bw was determined.
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