Copper cyanide

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2008

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

GLP compliance:

yes

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Copper cyanide

EC Number:

208-883-6

EC Name:

Copper cyanide

Cas Number:

544-92-3

Molecular formula:

CCuN

IUPAC Name:

λ¹-copper(1+) iminomethanide

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

CMC (carboxymethyl cellulose)

Doses:

300 and 2000 mg/kg

No. of animals per sex per dose:

3 females/dose for each test step

Control animals:

no

Results and discussion

Effect levels

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

>= 300 - <= 2 000 mg/kg bw

Based on:

test mat.

Mortality:

Death was observed on days 4, 8 and 11 of treatment in three animals of the dose group 2000 mg/kg.
One animal was found dead on day 5 of treatment in the dose group 300 mg/kg.

Clinical signs:

other: In clinical signs, subdued behavior, soiled perineal region, soft feces and liquid feces were observed in all animals of the treatment groups, and in 1st step 300 mg/kg, 2nd 300 mg/kg and 3ld step 2000 mg/kg thin appearance was observed in 2, 3 and 2 anim

Gross pathology:

Abnormal finding due to cannibalism was only observed in 1 animal of the 1st step 300 mg/kg group, and no treatment-related gross findings were observed in any groups.

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

The single oral treatment of copper cyanide at dose levels of 300 and 2000 mg/kg resulted in animal death, various clinical signs and a decrease in body weight. Therefore, the LD50 value of copper cyanide in female rats is ranked as a Category 4, according to the Globally Harmonized System (GHS) for the classification of chemicals which cause acute toxicity.