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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The potential of Aryl sulphonate condensate to induce skin sensitisation is expected to be driven by the capacity of its constituents to induce skin sensitisation. Based on a (Q)SAR assessment of the main constituents, no sensitisation is expected. The substance contains formaldehyde (CAS 50-00-0) a known skin sensitiser as a minor constituent <0.15 %w/w, however this is below the threshold for classification set in CLP Regulation (EC) 1272/2008, Annex I, 3.4.

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation: in vitro
Type of information:
other: Endpoint Expert Assessment
Adequacy of study:
key study
Study period:
March 2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Qualifier:
no guideline required
Principles of method if other than guideline:
An assessment was performed based on structures, molecular weights and toxicokinetics of the substance using the OECD QSAR Toolbox v4.2 to predict the skin sensitisation potential of Aryl sulphonate condensate.
GLP compliance:
no
Type of study:
other: An assessment was performed based on structures, molecular weights and toxicokinetics of the substance using the OECD QSAR Toolbox v4.2 to predict the skin sensitisation potential of Aryl sulphonate condensate.
Key result
Remarks on result:
other: Quantitative results were not determined as no test was performed
Interpretation of results:
GHS criteria not met
Conclusions:
An assessment of the potential for the constituents to induce skin sensitisation concluded that Aryl sulphonate condensate is not expected to meet the criteria for classification in accordance with Regulation (EC) 1272/2008.
Executive summary:

The potential of Aryl sulphonate condensate to induce skin sensitisation is expected to be driven by the capacity of its constituents to induce skin sensitisation. Based on a (Q)SAR assessment of the main constituents, no sensitisation is expected. The substance contains formaldehyde (CAS 50-00-0) a known skin sensitiser as a minor constituent <0.15 %w/w, however this is below the threshold for classification set in CLP Regulation (EC) 1272/2008, Annex I, 3.4.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

The potential of Aryl sulphonate condensate to induce skin sensitisation was assessed by (Q)SAR modelling of the constituents. It concluded that the substance did not meet the criteria for classification in accordance with Regulation (EC) 1272/2008.