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EC number: 202-261-8 | CAS number: 93-60-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LD50 was considered to be 2800 mg/kg bw when mice were treated with Methyl nicotinate orally.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from International Programme on Chemical Safety
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity of Methyl nicotinate in mice
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Methyl nicotinate
- Molecular formula (if other than submission substance): C7H7NO2
- Molecular weight (if other than submission substance): 137.137 g/mol
- Substance type: Organic
- Physical state: white solid powder - Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available.
- Doses:
- 2800 mg/kg bw
- No. of animals per sex per dose:
- No data available.
- Control animals:
- not specified
- Details on study design:
- No data available.
- Statistics:
- No data available.
- Preliminary study:
- No data available.
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 800 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- 50 % mortality was observed in rats at 2800 mg/kg bw
- Clinical signs:
- other: No data available.
- Gross pathology:
- No data available.
- Other findings:
- No data available.
- Interpretation of results:
- other: Not classified
- Conclusions:
- LD50 was considered to be 2800 mg/kg bw when mice were treated with Methyl nicotinate orally.
- Executive summary:
In acute oral toxicity study, mice were treated with Methyl nicotinate orally in the concentration of 2800 mg/kg bw. 50 % mortality was observed in rats at 2800 mg/kg bw. Therefore, LD50 was considered to be 2800 mg/kg bw when mice were treated with Methyl nicotinate orally.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 800 mg/kg bw
- Quality of whole database:
- Data is Klimisch 2 and from Joint FAO/WHO Expert Committee on Food Additives
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute oral toxicity:
In different studies, Methyl nicotinate (MN) has been investigated for acute oral toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments in rodents, i.e. most commonly in mice and rats for Methyl nicotinate. The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies.
In an experimental study given by Joint FAO/WHO Expert Committee on Food Additives (JECFA) (International Programme on Chemical Safety World Health Organization (IPCS), WHO FOOD ADDITIVES SERIES: 54, 2006), mice were treated with Methyl nicotinate orally in the concentration of 2800 mg/kg bw. 50 % mortality was observed in rats at 2800 mg/kg bw. Therefore, LD50 was considered to be 2800 mg/kg bw when mice were treated with Methyl nicotinate orally.
In another experimental study conducted by Nworguet al(Acta Poloniae Pharmaceutica - Drug Research, Vol. 64 No. 2 pp. 179-182, 2007), male and female mice were treated with Methyl nicotinate in the concentration of 1000, 2000, 3000 and 5000 mg/kg orally by gavage. 50 % mortality was observed in treated mice at 5000 mg/kg bw. Therefore, LD50 was considered to be 5000 mg/kg bw when male and female mice were treated with Methyl nicotinate orally by gavage.
Also it is supported by estimation done by using Danish QSAR , 50 % mortality observed at 3300 mg/kg bw . Therefore, estimated LD50 was considered to be 3300 mg/kg bw when rat were treated with Methyl nicotinate orally.
Thus, based on the above studies and predictions on Methyl nicotinate , it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, Methyl nicotinate can be “Not classified” for acute oral toxicity.
Justification for classification or non-classification
Based on the above studies and predictions on Methyl nicotinate , it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, Methyl nicotinate can be “Not classified” for acute oral toxicity.
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