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EC number: 202-261-8 | CAS number: 93-60-7
Endpoint summary
Administrative data
Description of key information
Biodegradation in water
Biodegradability of Methyl nicotinate (CAS no. 93 -60 -7) is predicted using QSAR toolbox version 3.3 with logKow as the primary descriptor (2017). Test substance undergoes 68.4% degradation by BOD in 28 days.Thus, based on percentage degradation, the test chemical Methyl nicotinate was estimated to be readily biodegradable in water.
Biodegradation in water and sediment
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound Methyl nicotinate (CAS No. 93 -60 -7). If released in to the environment, 24.3% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of Methyl nicotinate in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the Methyl nicotinate is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of Methyl nicotinate in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.0779%), indicates that Methyl nicotinate is not persistent in sediment.
Biodegradation in soil
The half-life period of test chemical Methyl nicotinate (CAS No. 93 -60 -7) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 75.3% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of Methyl nicotinate in soil is estimated to be 30 days (720 hrs). Based on this half-life value of Methyl nicotinate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Additional information
Biodegradation in water
Various predicted data for the target compound Methyl nicotinate (CAS No. 93 -60 -7) and various supporting studies for its read across substance were reviewed for the biodegradation end point which are summarized as below:
In a prediction done by SSS (2017) using OECD QSAR toolbox version 3.3 with logKow as the primary descriptor, percentage biodegradability of test chemicalMethyl nicotinate (CAS No. 93-60-7) was estimated. Test substance undergoes 68.4% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical Methyl nicotinate was estimated to be readily biodegradable in water.
In another prediction using the Estimation Programs Interface Suite (EPI suite, 2017), the biodegradation potential of the test compound Methyl nicotinate (CAS No. 93-60-7) in the presence of mixed populations of environmental microorganisms was estimated.The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI LInear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that Methyl nicotinate is expected to be readily biodegradable.
In a supporting weight of evidence study from authoritative database (J-CHECK. 2016), biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of read across substance 2 -benzofuran-1(3H)-one (CAS no. 87 -41 -2). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of read across substance was determined to be 95, 96 and 100% by BOD, TOC removal and HPLC parameter in 28 days. Thus, based on percentage degradation, 2 -benzofuran-1(3H)-one is considered to be readily biodegradable in nature.
For another read across chemical Benzoic acid (CAS no. 65 -85 -0), biodegradation study was conducted for evaluating the percentage biodegradability of read across substance Benzoic acid(HSDB, 2016). Sewage seed was used as a test inoculum. The percentage degradation of read across substance was determined to be 74% by BOD parameter in 5 days. Thus, based on percentage degradation, Benzoic acid is considered to be readily biodegradable in nature.
Another weight of evidence study of biodegradation was conducted for 14 days for evaluating the percentage biodegradability of read across substance Nicotinic acid (CAS no. 59 -67 -6) (OECD SIDS, 1993).The study was performed according to OECD Guideline 301E (Modified screening test) under aerobic conditions. The percentage degradation of read across substance was determined to be 100% by DOC removal in 14 days. Thus, based on percentage degradation, Nicotinic acid is considered to be readily biodegradable in nature.
On the basis of above results for target chemicalMethyl nicotinate(from OECD QSAR toolbox version 3.3 and EPI Suite, 2017) and for its read across substance (from authoritative database HSDB and J-CHECK, 2016 and secondary source OECD SIDS, 1993), it can be concluded that the test substanceMethyl nicotinatecan be expected to be readily biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound Methyl nicotinate (CAS No. 93 -60 -7). If released in to the environment, 24.3% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of Methyl nicotinate in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the Methyl nicotinate is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of Methyl nicotinate in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.0779%), indicates that Methyl nicotinate is not persistent in sediment.
Biodegradation in soil
The half-life period of test chemical Methyl nicotinate (CAS No. 93 -60 -7) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 75.3% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of Methyl nicotinate in soil is estimated to be 30 days (720 hrs). Based on this half-life value of Methyl nicotinate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
On the basis of available information, the test substance Methyl nicotinate can be considered to be readily biodegradable in nature.
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