Registration Dossier
Registration Dossier
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EC number: 201-325-2 | CAS number: 81-11-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
NOAEL > 1000 mg/kg bw/day
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
No effects on clinical signs, body weight changes, food consumption or necropsy findings in either sex were detected.
Testicular and epididymal weights were similar among all four groups (No histopathological changes in these reproductive organs of the male rats.)
Parental animals exhibited no effects on reproductive parameters including the copulation index, fertility index, gestation index, delivery index, parturition or maternal behavior.
There were no significant differences in the number of offspring or live offspring, sex ratio, live birth index, viability index, or body weight. No abnormal findings attributable to the test substance were noted in external examination, clinical signs or necropsy of the offspring.
Short description of key information:
The substance is not considered to be toxic to reproduction.
Effects on developmental toxicity
Description of key information
The substance is not considered to be toxic to reproduction.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
No effects on clinical signs, body weight changes, food consumption or necropsy findings in either sex were detected.
Testicular and epididymal weights were similar among all four groups (No histopathological changes in these reproductive organs of the male rats.)
Parental animals exhibited no effects on reproductive parameters including the copulation index, fertility index, gestation index, delivery index, parturition or maternal behavior.
There were no significant differences in the number of offspring or live offspring, sex ratio, live birth index, viability index, or body weight. No abnormal findings attributable to the test substance were noted in external examination, clinical signs or necropsy of the offspring.
Justification for classification or non-classification
There are conclusive but not sufficient data for classification of the substance with regard to reproduction toxicity.
The substance is not classified for this endpoint in accordance to the CLP Regulation (EC) No 1272/2008.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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