Brief Profile

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Please be aware that the REACH registration parts of this Brief Profile are no longer maintained; they remain frozen as of 19th May 2023. All other data parts (substance identity, C&L, key regulatory lists etc. are up to date).

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
226-109-5
CAS no.:
5281-04-9
Index number:
Molecular formula:
C18H12CaN2O6S
SMILES:
[Ca++].CC1=CC(=C(C=C1)\N=N\C1=C(O)C(=CC2=CC=CC=C12)C([O-])=O)S([O-])(=O)=O
InChI:
InChI=1S/C18H14N2O6S.Ca/c1-10-6-7-14(15(8-10)27(24,25)26)19-20-16-12-5-3-2-4-11(12)9-13(17(16)21)18(22)23;/h2-9,21H,1H3,(H,22,23)(H,24,25,26);/q;+2/p-2/b20-19+;
Type of substance:
Mono constituent substance, UVCB
Origin:
Organic
Registered compositions:
40
Of which contain:
2 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

According to the notifications provided by companies to ECHA in REACH registrations no hazards have been classified.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is harmful if inhaled.

Breakdown of all 719 C&L notifications submitted to ECHA

Not Classified
Acute Tox. 4 H332
Aquatic Chronic 3 H412
STOT RE 2 H373
Skin Sens. 1 H317
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

Nanomaterial form

Substance is known to be on the EEA market in nanomaterial form, as indicated in the REACH registered substance factsheet(s), and as listed in the EUON Nanomaterials in the EU market list.

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 49 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:
Nanomaterials in the EU Market

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: coating products, inks and toners and polymers.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance is used in the following activities or processes at workplace: high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding) and the low energy manipulation of substances bound in materials or articles.

Release to the environment of this substance can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal) and of articles where the substances are not intended to be released and where the conditions of use do not promote release. Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

This substance can be found in complex articles, with no release intended: vehicles. This substance can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones) and wood (e.g. floors, furniture, toys).

This substance is used in the following products: inks and toners, coating products, finger paints, metal surface treatment products and non-metal-surface treatment products.

This substance is used in the following areas: printing and recorded media reproduction, formulation of mixtures and/or re-packaging and building & construction work. This substance is used for the manufacture of: machinery and vehicles and fabricated metal products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, roller or brushing applications, non-industrial spraying, treatment of articles by dipping and pouring, hand mixing with intimate contact only with personal protective equipment available and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following products: coating products, inks and toners and polymers.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, transfer of substance into small containers, laboratory work, production of mixtures or articles by tabletting, compression, extrusion or pelletisation and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Release to the environment of this substance can occur from industrial use: formulation of mixtures and formulation in materials.

This substance is used in the following products: inks and toners, coating products, polymers and finger paints.

This substance is used in the following areas: formulation of mixtures and/or re-packaging and printing and recorded media reproduction. This substance is used for the manufacture of: plastic products and rubber products.

This substance is used in the following activities or processes at workplace: mixing in open batch processes, transfer of chemicals, transfer of substance into small containers, closed batch processing in synthesis or formulation and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: in the production of articles.

This substance is used in the following activities or processes at workplace: transfer of chemicals, batch processing in synthesis or formulation with opportunity for exposure, laboratory work and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • ABACOLOR SRL, via Monte Croce 4/c 35031 Abano Terme Padova Italy
  • Adriaanse Import & Export, Adriaan Mulderweg 9-11 5657 EM Eindhoven Netherlands
  • ARCHROMA IBÉRICA, S.L., ZAL-Prat c/Cal Coracero, 46-56 08820 El Prat de Llobregat Spain
  • Brenntag Chemicals Distribution (Ireland) Ltd, Unit 405 Greenogue Business Park, Rathcoole Dublin 24 Dublin Ireland
  • Brilliant Chem Europe GmbH, Muffeter Weg 37 52064 Aachen Germany
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77, Dublin, Ireland D02 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED (OR for HANGZHOU HONGYAN PIGMENT CHEMICAL CO.,LTD.), Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Colors & Effects Netherlands B.V., Sortieweg 39 6219NT Maastricht Netherlands
  • CSI-OR28DUB, Block C Ardilaun Court 112-114 St. Stephen’s Green D02 TD28 Dublin Ireland
  • CSI-OR45DUB, Block C Ardilaun Court 112-114 St. Stephen’s Green D02 YP23 Dublin Ireland
  • Daicolor Italy OR, Via Vittor Pisani 28 20124 Milano Italy
  • Daito Kasei Europe, 62 Bld Henri Navier Taverparc 95150 Taverny France
  • EIGENMANN & VERONELLI IBÉRICA, S.L., Polígono Industrial La Pedrosa C/ Miguel Hernández, 42 - 44 Nave A 08908 L’Hospitalet de Llobregat - Barcelona Spain
  • Flint CPS Inks Germany GmbH, Sieglestrasse 25 70464 Stuttgart Germany
  • Flint CPS Inks Germany GmbH - CN, Sieglestrasse 25 70464 Stuttgart Germany
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17 223 63 Lund Sweden
  • Global Product Compliance (Europe) AB on behalf of Neelikon Food Dyes & Chemicals Ltd, IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden
  • Gustav Grolman GmbH & Co. KG, Fuggerstr. 1 41468 Neuss Germany
  • Hercules Pigments Pvt Ltd (represented by Luxcontrol S.A.), 1, Avenue des Terres Rouges 4331 Esch sur Alzette Luxembourg
  • Heubach Colorants Germany GmbH, Brüningstrasse 50 65929 Frankfurt am Main Germany
  • Heubach Colorants Germany GmbH - BR01, Brüningstrasse 50 65929 Frankfurt am Main Germany
  • Intertek Deutschland GmbH, Stangenstrasse 1 D-70771 Leinfelden-Echterdingen D-70771 Leinfelden-Echterdingen Germany
  • Intertek Deutschland GmbH CZDN, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • L.C.M. TRADING SPA, via Mazzini 33 20099 Sesto San Giovanni Lombardia Italy
  • Labcorp Development SA 032, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain
  • MHM Holding GmbH, Sonnenallee 1 D-85551 Kirchheim Germany
  • Only representative (No publishable name), null
  • REACH24H CONSULTING GROUP, Suite 1E, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • REACHLINKED OÜ, Ahtri tn 12 10151 Tallinn Estonia
  • Roha Polska sp. z o.o. , ul. Połczyńska 31A , 01-377 Warszawa 01-377 Warszawa Poland
  • RSI ChemRep Europe Ltd (D002), 27-30 Merchants Quay Merchants House 8 Dublin Ireland
  • Sudarshan Europe B.V., Kingsfordweg 151 1043 GR Amsterdam Noord-Holland Netherlands
  • Sun Chemical B.V., Leeuwenveldseweg 3-t 1382 LV Weesp Netherlands
  • Sun Chemical Colors & Effects GmbH, An der Rheinschanze 1 67059 Ludwigshafen Germany
  • Synthesia, a.s., Semtín103 53002 Pardubice Czech Republic
  • Trust Chem Europe B.V., Bergpoortstraat 65 NL-7411 CL Deventer Netherlands
  • UKSEUNG Europe GmbH, Hauptstrasse 14 63860 Rothenbuch Germany
  • Union Colours B.V., ESP 238 5633 AC Eindhoven Netherlands
  • Xerox (Europe) Limited, Ballycoolin Business Park Blanchardstown Dublin 15 Dublin Ireland
  • Xerox Manufacturing (Nederland) BV, Maasheseweg 89-91 5804 AB Venray Limburg Netherlands
  • Zebra A/S, Strandgade 71-73 1401 Copenhagen Denmark
  • [Confidential], [Confidential]
  • Daicolor Italy S.R.L., Via Vittor Pisani 28 20124 Milano Italy
  • DyStar Colours Distribution GmbH, Am Prime-Parc 12 65479 Raunheim Germany
  • Flint CPS Inks Germany GmbH - NA, Sieglestrasse 25 70464 Stuttgart Germany
  • Kao Chemicals Europe, S.L. (2), Puig dels Tudons, 10 08210 Barbera del Valles Barcelona Spain
  • Labcorp Development SA 023, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 - 5 Planta 28050 Madrid Spain
  • Sun Chemical A/S, Københavnsvej 112 4600 Køge Denmark

Substance names and other identifiers

Calcium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate
EC Inventory, REACH pre-registration, Other
Calcium 3-Hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate
REACH pre-registration, Other, Cosmetic Products Regulation, Annex IV - Allowed Colorants
(4Z)-4-[(4-methyl-2-sulfonatophenyl)hydrazinylidene]-3-oxonaphthalene-2-carboxylate
C&L Inventory
2-Naphthalenecarboxylic acid, 3-hydroxy-4-[(4-methyl-2-
C&L Inventory
3-Hydroxy-4-[(4-methyl-2-sulfophenyl)azo]-2-naphthalenecarboxylic acid, calcium salt (1:1)
C&L Inventory
3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate
C&L Inventory
Bricofor Rubine 4BSP
Registration dossier
C. I. Pigment 57:1
Registration dossier
C. I. Pigment 57:1
Registration dossier
C.I. Pigment Red 57:1
C&L Inventory
C.I. Pigment Red 57:1
C&L Inventory, Registration dossier
C.I. PIGMNET RED 57:1
Registration dossier
C.I.Pigment Red 57:1
C&L Inventory
calcium (4Z)-4-[(4-methyl-2-sulfonatophenyl)hydrazinylidene]-3- oxonaphthalene-2-carboxylate
C&L Inventory
calcium (4Z)-4-[(4-methyl-2-sulfonatophenyl)hydrazinylidene]-3-oxonaphthalene-2- carboxylate
C&L Inventory
Calcium (4Z)-4-[(4-methyl-2-sulfonatophenyl)hydrazinylidene]-3-oxonaphthalene-2-carboxylate
C&L Inventory
calcium (E)-3-hydroxy-4-((4-methyl-2-sulfonatophenyl)diazenyl)-2-naphthoate
C&L Inventory
Calcium 3-hydroxy-4-[(4-methyl-2-sulfonatophenyl)diazenyl]-2-naphthoate
C&L Inventory, Registration dossier
calcium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)
C&L Inventory
calcium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2
C&L Inventory
calcium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-
C&L Inventory
Calcium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate
C&L Inventory, Registration dossier
Calcium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate
C&L Inventory, Registration dossier
calcium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate; C.I. Pigment Red 57:1;D+C RED 7
Registration dossier
Calcium 3-hydroxy-4-[(E)-2-(4-methyl-2-sulfonatophenyl)diazen-1-yl]naphthalene-2-carboxylate
Registration dossier
calcium 3-hydroxy-4-[(E)-2-(4-methyl-2-sulfophenyl)diazen-1-yl]naphthalene-2-carboxylate
Registration dossier, Other
Calcium bis[2-(3-carboxy-2-hydroxynephthylazo)-5-methylbenzenesulfonate]
C&L Inventory
calcium(4Z)-4-[(4-methyl-2-sulfonatophenyl)hydrazinylidene]-3-oxonaphthalene-2-carboxylate
C&L Inventory, Registration dossier
calcium(4Z)-4-[(4-methyl-2-sulphonatophenyl)hydrazinylidene]-3-oxonaphtalene-2-carboxylate
C&L Inventory
calcium;4-[(4-methyl-2-sulfophenyl)diazenyl]-3-oxidonaphthalene-2-carboxylate
Registration dossier
CARMINE GB PR 57:1
C&L Inventory
D + C Red 7 (Lithol Rubine B, Ca Lake + Lithol Rubine B, Ca Salt)
Registration dossier
D+C Red No. 7, Unipure Red LC 3079
Registration dossier
DC Red 7
Registration dossier
Lithol Rubin BCA
C&L Inventory
Lithol rubine Ca
C&L Inventory
Panax Carmine 157, Panax Carmine HF-S(N), Panax Carmine 570W
Registration dossier
pigment red 54:1
C&L Inventory
Pigment Red 57
Registration dossier
Pigment Red 57.1
Registration dossier
PIGMENT RED 57:1
Registration dossier
PR57:1
Registration dossier
Rubine red pigment
C&L Inventory
C. I. Pigment Red 57:1
Registration dossier
C.I. 15850:1
Registration dossier
C.I. Pigment Red 57:1
Registration dossier
D + C Red 7 (Lithol Rubine B, Ca Lake + Lithol Rubine B, Ca Salt)
Registration dossier
LIONOL RED 6B 4240-P-
Registration dossier
LIONOL RED 6B 4254-P-
Registration dossier
LIONOL RED 6B FG-4306-G
Registration dossier
LIONOL RED 7B FG-4403-S
Registration dossier
Neelicert D + C Red 7Lavanya IndicaLithol RubinNeelicet D + C Red 7 Ca LakeLavanya ElegansPIGMENT RED 57:1
Registration dossier
PR 57:1
Registration dossier
SEIKAFAST CARMINE 6B 1476T-7
Registration dossier
SYMULER Brilliant Carmine 6B
Registration dossier
Versal Red 4BP
Registration dossier
Versal Red F6RO
Registration dossier
Versal Red F6RW
Registration dossier
Versal Red F6RWB
Registration dossier
Versalová červeň 4BP
Registration dossier
Versalová červeň F6RO
Registration dossier
Versalová červeň F6RW
Registration dossier
Versalová červeň F6RWB
Registration dossier
Pigment Red 57:1
REACH pre-registration
106008-82-6
CAS number
Other
11145-41-8
CAS number
Other
116357-55-2
CAS number
Other
116711-94-5
CAS number
Other
12238-33-4
CAS number
Other
12238-35-6
CAS number
Other
12238-36-7
CAS number
Other
12238-46-9
CAS number
Other
12238-47-0
CAS number
Other
1255344-55-8
CAS number
Other
128282-14-4
CAS number
Other
1325-10-6
CAS number
Other
149003-64-5
CAS number
Other
1818339-54-6
CAS number
Other
1878210-16-2
CAS number
Other
217821-04-0
CAS number
Other
37340-13-9
CAS number
Other
39340-05-1
CAS number
Other
5281-04-9
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, Cosmetic Products Regulation, Annex IV - Allowed Colorants
53028-84-5
CAS number
Other
53612-29-6
CAS number
Other
57176-64-4
CAS number
Other
57917-29-0
CAS number
Other
60748-28-9
CAS number
Other
69458-81-7
CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 6 studies submitted
  • 3 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [3]
C Form
Solid: particulate/powder (67%), Powder (33%) [3]
C Odour
Other (100%) [1]
C Substance type
Organic (100%) [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 5 summaries submitted
  • 5 summaries processed
Physical state at 20°C and 1013 hPa
Solid (100%)
Form
Solid: particulate/powder (100%)
Colour
red (100%)

Melting/freezing point

Study results
  • 8 studies submitted
  • 1 study processed
R Melting / freezing point
400 °C @ 97.69 kPa [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
400 °C

Boiling point

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 5 studies submitted
  • 3 studies processed
R Density
0.352 - 1.7 g/cm³ @ 20 °C [2]
R Relative density
1 700 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Relative density at 20°C
0.352 - 1.7

Vapour pressure

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Vapour pressure
0 Pa @ 25 °C

Partition coefficient

Study results
  • 6 studies submitted
  • 2 studies processed
R Log Pow
0.65 @ 23 °C and pH 4.5 - 5 [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 2 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
Log Kow (Log Pow)
0.65 - 2.4 @ 23 - 25 °C

Water solubility

Study results
  • 8 studies submitted
  • 2 studies processed
R Water solubility (mass/vol.)
1.2 - 1.3 mg/L @ 23 °C and pH 4.5 - 5 [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Water solubility
8.9 mg/L @ 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 3 studies submitted
  • 1 study processed
R Flash point
250 °C @ 97.69 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Flash point at 101 325 Pa
250 °C

Auto flammability

Study results
  • 13 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2 1
Supporting study 10
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 15 studies submitted
  • 2 studies processed
C Interpretation of results
GHS criteria not met (100%) [2]

Type of Study provided
Studies with data
Key study 4
Supporting study 7
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 4
Exposure cons.
Other
C Summaries
  • 3 summaries submitted
  • 2 summaries processed
Flammability
Not classified (100%)

Explosiveness

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 1
Exposure cons.
Other 1
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Oxidising
Non oxidising (67%), No (33%)

Oxidation reduction potential

Data not provided by the registrant

pH

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 4 studies submitted
  • 2 studies processed
C Dissociating properties
No (100%) [2]
R Dissociation constant
0.05 @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence 1 1
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in soil
4 months

Biodegradation in water - screening tests

Study results
  • 6 studies submitted
  • 2 studies processed
C Interpretation of results
Not readily biodegradable (100%) [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 2 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 3 summaries submitted
  • 2 summaries processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3
Supporting study 3 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - L/kg ww
6.9 L/kg ww

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 5 studies submitted
  • 2 studies processed
R Koc
8 321 L/kg @ 25 °C [1]
R log Koc
3.679 dimensionless @ 25 °C [1]

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence 1 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Koc at 20°C
8 321

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 3 summaries submitted
  • 3 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 30 µg/L (1)
Intermittent releases (freshwater) 330 µg/L (1)
Marine water 3 µg/L (1)
Intermittent releases (marine water) 33 µg/L (1)
Sewage treatment plant (STP) 10 mg/L (1)
Sediment (freshwater) 10 - 25.1 mg/kg sediment dw (2)
Sediment (marine water) 1 - 2.51 mg/kg sediment dw (2)
Hazard for Air
Air No hazard identified (2)
Hazard for Terrestrial Organism
Soil 5 - 10 mg/kg soil dw (2)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (2)

Short–term toxicity to fish

Study results
  • 12 studies submitted
  • 4 studies processed
P/RResults
LC50 (4 days) 100 mg/L [4]
NOEC (4 days) 100 mg/L [2]

Type of Study provided
Studies with data
Key study 5 1
Supporting study 4
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 6 studies submitted
  • 2 studies processed
P/RResults
EC50 (48 h) 100 mg/L [2]
EC0 (48 h) 50 mg/L [2]
EC100 (48 h) 100 mg/L [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 8 studies submitted
  • 3 studies processed
P/RResults
EC50 (72 h) 941 - 190 000 µg/L [5]
NOEC (72 h) 531 - 5 800 µg/L [5]
LOEC (72 h) 3.2 - 10 mg/L [2]
EC10 (72 h) 760 - 102 000 µg/L [2]
EC90 (72 h) 100 mg/L [2]

Type of Study provided
Studies with data
Key study 4 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 2 summaries processed
EC50 for freshwater algae
190 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 7 studies submitted
  • 1 study processed
P/RResults
NOEC (3 h) 100 mg/L [1]

Type of Study provided
Studies with data
Key study 3 1
Supporting study
Weight of evidence 2 1
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 1 summary processed
EC50 for microorganisms
10 g/L

Sediment toxicity

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOEC (28 days) 1 000 mg/kg sediment dw [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 6 studies submitted
  • 1 study processed
P/RResults
LC50 (14 days) 1 g/kg soil dw [1]
LC0 (14 days) 1 g/kg soil dw [1]
LC100 (14 days) 1 g/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 4.4 mg/m³ repeated dose toxicity
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 570 µg/kg bw/day repeated dose toxicity
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.1 mg/m³ repeated dose toxicity
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 133 µg/kg bw/day repeated dose toxicity
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 600 µg/kg bw/day repeated dose toxicity
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
Low hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential
Absorption values
Oral: 50 %
Dermal: 50 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 22 studies submitted
  • 8 studies processed
P/RResults
LD50 2 000 - 5 000 mg/kg bw (rat) [6]
LD0 5 000 mg/kg bw (rat) [2]
LD50 4 166.66 - 16 000 mg/kg bw (mouse) [2]
M/CInterpretations of results
GHS criteria not met [1]

Type of Study provided
oral
Studies with data
Key study 3
Supporting study 13
Weight of evidence 6
Other
Data waiving
no waivers
inhalation
  • 5 studies submitted
  • 3 studies processed
P/RResults
LC50 (4 h) 1.518 - 4.76 mg/L air (rat) [3]
LC0 (4 h) 1.518 mg/L air (rat) [2]
M/CInterpretations of results
Study cannot be used for classification [1]

inhalation
Studies with data
Key study 2 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
dermal
  • 11 studies submitted
  • 5 studies processed
P/RResults
LD50 2 000 - 2 500 mg/kg bw (rat) [5]
LD0 2 500 mg/kg bw (rat) [2]
M/CInterpretations of results
GHS criteria not met [1]

dermal
Studies with data
Key study 2
Supporting study 6
Weight of evidence 3
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 2 summaries processed
Oral route:
No adverse effect observed LD50 5 000 mg/kg bw
Inhalation route:
No adverse effect observed LC50 1.518 mg/L air
Dermal route:
No adverse effect observed LD50 2 500 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 39 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3
Supporting study 33
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: eye
  • 33 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 3
Supporting study 21
Weight of evidence 7
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 4
Supporting study 3
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 11 studies submitted
  • 3 studies processed
P/RResults
NOEL (rat): 25 - 100 mg/kg bw/day [6]

Type of Study provided
Study data: oral
Studies with data
Key study 3 2
Supporting study 4 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: dermal
  • 3 studies submitted
  • 1 study processed
P/RResults
NOAEL (mouse): 130.6 mg/kg bw/day [1]

Study data: dermal
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 2 summaries processed
Oral route - systemic effects:
Adverse effect observed NOAEL 25 mg/kg bw/day (subacute, rat)
Dermal route - systemic effects:
No adverse effect observed NOAEL 50 mg/kg bw/day (chronic, mouse)

Genetic toxicity

Study results
Study data: in vitro
  • 36 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 12
Supporting study 24
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 2 summaries processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No study available

Carcinogenicity

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 11 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 3 2
Supporting study 4
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: developmental
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 2 summaries processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 1 000 mg/kg bw/day (subacute, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 50 mg/kg bw/day (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant