Registration Dossier
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EC number: 271-347-5 | CAS number: 68541-50-4
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No effects on Daphnia magna up to the limit of water solubility (OECD 211).
Key value for chemical safety assessment
Additional information
Since no studies on long-term toxicity to aquatic invertebrates are available for 2-ethyl-2-(((1-oxoisooctadecyl)oxy)methyl)-1,3-propanediyl bis (isooctadecanoate) (CAS 68541-50-4), the assessment of chronic toxicity was based on a study conducted with a category member, for which data is available, Fatty acids, C16-18 and C18-unsatd., triesters with trimethylolpropane (CAS 68002-78-8) as part of a read across approach. The read across is suitable due to the similar fatty acid chain length of both substances. This is in accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 6.1 and within the analogue justification section 13. The available GLP study on the long-term toxicity of Fatty acids, C16-18 and C18-unsatd., triesters with trimethylolpropane (CAS 68002-78-8was performed according to the OECD guideline 211 (Grell, 2013). The test organism Daphnia magna was exposed to the test substance in a semi-static system for 21 days. The substance did not have any effect on the mobility or reproduction of Daphnia magna at the tested concentration. A NOELR ≥ 0.11 g/L is reported. The concentration is based on the water accommodated fraction (WAF). Due to the structural and profile similarities of the two substances, it can be concluded that toxicological long-term effects on aquatic invertebrates are not to be expected up to the limit of water solubility (< 0.05 mg/L; Frischmann, 2012) for 2-ethyl-2-(((1-oxoisooctadecyl)oxy)methyl)-1,3-propanediyl bis (isooctadecanoate) (CAS 68541-50-4). As it can be seen in the data matrix of the category justification in section 13 and the overall endpoint summary IUCLID 6.1, all reliable data in the category support the hazard assessment of each category member by showing a consistent pattern of results, i.e. no toxic effects to aquatic organisms were observed up to the limit of water solubility.
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