Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-120-3 | CAS number: 103-53-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 973
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Toxic properties after a single oral dose of the test substance were investigated by observation for a period of 15 days.
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- Phenethyl cinnamate
- EC Number:
- 203-120-3
- EC Name:
- Phenethyl cinnamate
- Cas Number:
- 103-53-7
- Molecular formula:
- C17H16O2
- IUPAC Name:
- phenethyl cinnamate
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sunflower-seed oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20-45%
- Amount of vehicle (if gavage):0.2-0.5 mL/kg bw
- Justification for choice of vehicle: because of low solubility of the substance - Doses:
- 0.2 to 0.5 mL/kg bw of 20-45% solution in the vehicle
- No. of animals per sex per dose:
- 6 animals/sex/dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 15 days
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 4 500 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008
- Conclusions:
- The test substance has a LD50 of 4500 mg/kg bw given as a single dose.
- Executive summary:
The study has been performed in order to investigate the toxic propreties of the test substance.
Each groups of 6 males and 6 females of guinea pigs were fed through a stomach tube perorally in the form of a 20 -45% solution in sunflower-seed oil (0.2 - 0.5 mL per kg bw) given as a single dose.
The animals were observed for 15 days.
No differences in the sex sensitivity of these animals were observed.
As a result, the test substance can be referred to as a low-toxic compound with an LD50 of 4500 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
