Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-120-3 | CAS number: 103-53-7
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06.08 - 13.12.2004
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- 1989
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 4.4
- Temp.:
- 35 °C
- Remarks on result:
- other: No information on pH range was given in report
- Conclusions:
- The partition coefficient n-octanol/water of the test item, log Pow was determined to be 4.4 at 35 °C.
- Executive summary:
In the current study the partition coefficient (n-octanol/water) of the test item was determined according to OECD Guideline 117 (2004).
The test was performed with a concentration of 38.1 mg/100 mL of test item in acetonitrile : water (60:40). Samples were analysed via HPLC on a C18 column with a refractive index detection.
Calibration was performed using 7 reference items with known log Pow values. The dead time was determined using thiourea. After calibration, a mixture containing the 7 reference items and thiourea was measured twice, once before and once after the measurement of the test item. The validity criteria were reached.
The experimental value for the log Pow was in relative good agreement with the partition coefficient estimated with KOWWIN software, which reported log Pow of 4.56.
From the two retention times derived for the test item, a mean retention time was calculated from which subsequently the log Pow value was derived.
The partition coefficient n-octanol/water of the test item, log Pow was determined to be 4.4 at 35 °C.
Reference
Description of key information
The partition coefficient n-octanol/water of the test item, log Pow was determined to be 4.4 at 35 °C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 4.4
- at the temperature of:
- 35 °C
Additional information
One study is available for this endpoint. The partition coefficient (n-octanol/water) of the test item was determined according to OECD Guideline 117.
From the two retention times derived for the test item, a mean retention time was calculated from which subsequently the log Pow value was determined to be 4.4 at 35°C.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
