7,16-dichloro-6,15-dihydroanthrazine-5,9,14,18-tetrone

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

April 30, 2015 - May 08, 2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

no

Type of method:

flask method

Key result

Water solubility:

< 1 other: mg (TOC) /L

Conc. based on:

test mat.

Loading of aqueous phase:

25 mg/L

Incubation duration:

24 - 72 h

Temp.:

20 °C

pH:

6

Remarks on result:

not determinable because of methodological limitations

 Individual results

 Preliminary visual estimation of the water solubility

Different amounts of the test item were stirred in 100 mL or 500 mL distilled water and the mixtures were visually checked for any undissolved parts.Table 2 shows the results from the preliminary test.

 

Table:Appearance of the test mixtures

Amount of test item in mg		Total volume in mL		Appearance of mixture
9.6		100		undissolved^1)
10.6		500		undissolved^1)
2.4		500		undissolved^1)

¹⁾: After adding the indicated amount of water, the solution was stirred for approx. 72 h.

The preliminary visual experiments showed that the solubility of the test item in water is below 5 mg/L (without correction for the purity). As the test item is insoluble in organic solvents, it is impossible to coat the sea sand of the columns with the test item. For this reason, the column elution method is not applicable and the water solubility had to be determined by the flask method.

Results of the flask method

After the equilibration time, precipitate was observed in the flasks of the experiments excluding in the blank experiment.The water solubility was calculated from the measured and unrounded concentration values and not from the rounded values given in the following table.

Table: Solubility of the test item in water

Experiment	24 h experiment	48 h experiment	72 h experiment	Blank experiment (72 h)
Amount of test item [mg]	5.5	4.8	4.9	--
Amount of distilled water [mL]	200	200	200	200
Stirring time at 30 °C [h]	24	48	72	72
pH at 23°C	6.0	6.0	5.8	5.9
Measured TOC concentration [mg C/L]	< 0.507	< 0.507	< 0.507	< 0.507

 

The TOC concentration in the aqueous samples was determined to be: < 1 mg (TOC) / L

Conclusions:

The water solubility of the test item is below the limit of quantification (1 mg (TOC)/L)

Executive summary:

The water solubility c_S of the test item was determined at a temperature of 20 °C according to OECD 105 and the total organic carbon content (TOC) was measured. It was determined to be: < 1 mg (TOC) / L.

Description of key information

The water solubility of the test item was determined at a temperature of 20 °C according to OECD 105 and the total organic carbon content (TOC) was measured. It was determined to be: < 1 mg (TOC) / L.

Additional information

The water solubility was found to be below the quantification limit of 1 mg/l.