Registration Dossier
Registration Dossier
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EC number: 221-761-7 | CAS number: 3228-02-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Mean 48h-EC50 between experimental and predicted values:
48h-EC50 = 6.2 mg/L
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 6.2 mg/L
Additional information
The 48 h-EC50 for the registered substance to Daphnia magna is between 3.7 based on a High Accuracy QSAR and 9.2 mg/L based on a recent laboratory study (LPL, 2015), performed according to GLP, using the geometric means of the exposure concentrations. A third study, rated klimisch 4 as non-GLP and conducted after 2008 but otherwise well conducted, was also included in the mean calculation as it's 48h EC50 value of 5.7 mg/L fitted well with the other two data points. As the experimental data are very close to the predictions, the supporting experimental data are used to calculate a mean value of the studies.The mean 48 h EC50 to be used in risk assessment for this endpoint is 6.2 mg/L.
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