Registration Dossier
Registration Dossier
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EC number: 225-863-2 | CAS number: 5124-30-1
Endpoint summary
Administrative data
Description of key information
Additional information
Aquatic bioaccumulation
4,4’-Methylenedicyclohexyl diisocyanate is characterized by a BCF of 10186 being calculated with BCFWIN v. 2.17 (Currenta, 2009a). However, the direct and indirect exposure of aquatic organisms is unlikely because 4,4’-methylenedicyclohexyl diisocyanate hydrolysis rapidly in water within 2 hours (half-life 1.97 hours).
The hydrolysis product of 4,4’-methylenedicyclohexyl diisocyanate with a calculated bioconcentration factor of 7.3 does not have a high bioaccumulation potential (Currenta, 2009b).
The following information is taken into account for any hazard / risk / bioaccumulation assessment:
4,4'-Methylenedicyclohexyl diisocyanate hydrolyses rapidly in the presence of water with a half life of approximately 2 hours. Therefore a risk estimation regarding the bioaccumulation potential of 4,4'methylenedicyclohexyl diisocyanate on the basis of a log Kow or a BCF, determined by QSAR, is misleading. A calculated theoretical log Kow or BCF value reflects the undissociated and unreacted molecule without influence of water.
However, the substance is not persistent in water due to the rapid hydrolysis. Therefore it is not bio-available. Possible hydrolysis products are less lipophilic. On the basis of these information it can be expected that relevant bioaccumulation of 4,4'-methylenedicyclohexyl diisocyanate does not occur.
Terrestrial
bioaccumulation
Not applicable.
Secondary poisoning
Because of the rapid hydrolysis of 4,4'-methylenedicyclohexyl diisocyanate in water, it is not expected that this substance will bioconcentrate in aquatic organisms, or bioaccumulate in the food chain. No information on BCFs and food chain bioaccumulation could be found for 4,4'-methylenedicyclohexyl diisocyanate in the available literature; however, a BCF of approximately 7 was calculated for the hydrolysis product 4,4’-methylenedicyclohexyl diamine (CAS number 1761-71-3) which indicates a very low bioaccumulation potential. For this reason, there is no risk for secondary poisoning. It is not required to carry out a risk characterisation for secondary poisoning.
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