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EC number: 918-594-3 | CAS number: 7723-14-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well performed and reported non GLP study similar to current OECD 404.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: FDA, 16 CFR 1500.41 91 26,141
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- 24 h exposure
- GLP compliance:
- no
- Remarks:
- study performed before GLP guidelines
Test material
- Reference substance name:
- phosphorus
- EC Number:
- 918-594-3
- Cas Number:
- 7723-14-0
- Molecular formula:
- (P)n (Phosphorus red modification)
- IUPAC Name:
- phosphorus
- Reference substance name:
- Phosphorus
- EC Number:
- 231-768-7
- EC Name:
- Phosphorus
- Cas Number:
- 7723-14-0
- IUPAC Name:
- phosphine
- Details on test material:
- - Name of test material (as cited in study report): oiled red phosphorus Albright and Wilson, LDT. Lot LT 22 RED PHOSPHORUS)
- Substance type: element
- Physical state: solid / powder
- Analytical purity: > 94,6 % +- 1,20 %
- Impurities (identity and concentrations): < 0,0055 % +- 0,0020 % yellow phosphorus
- Composition of test material, percentage of components:approx. 94,6 % total phosphorus, 0,08 % +- 0,010 % mineral oil
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: B and H Rabbitry, Rockville, MD, USA
- Age at study initiation: 10 week old
- Housing: wired bottom cages
- Diet (e.g. ad libitum): Purina Rat Chow
- Water (e.g. ad libitum): Acified water (pH 2.5)
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 72° to 76°F
- Humidity (%): 39 to 54 percent relative humidity
- Photoperiod (hrs dark / hrs light): 12h dark / 12h with artificial illumination.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- other: sterile isotonic saline solution
- Controls:
- no
- Amount / concentration applied:
- 0.5 g of red phosphorus was mixed with 0,5 ml sterile isotonic saline solution
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours
- Number of animals:
- six
- Details on study design:
- TEST SITE
- Area of exposure: 1 inch square
- Type of wrap if used: plastic
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no washing done
- Time after start of exposure:24 hours
SCORING SYSTEM: see table below
Red phosphorus is introduced under the 1X1 inch gauze patch. The gauze patch is pressed down firmly to assure uniform contact with the skin. The trunks of the animals are then securely wrapped with an impervious material plastic wrap) and the animals are placed in restaining collars.
Results and discussion
In vivo
Results
- Basis:
- mean
- Time point:
- other: 24 and 72h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: n.a.
- Remarks on result:
- other: the test material does not have irritation potential
- Irritant / corrosive response data:
- The test material does not have irritation potential
- Other effects:
- Clinical signs indicative of systemic toxicity were not observed during the course of this study.
Any other information on results incl. tables
Erythema and Eschar Formation | Edema Formation | ||||||||
Rabbit | Intact Skin | Abraded Skin | Intact Skin | Abraded Skin | |||||
number | 24hr | 72hr | 24hr | 72hr | 24hr | 72hr | 24hr | 72hr | |
2354D | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | |
2355D | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | |
2356D | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | |
2357D | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | |
2358D | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | |
2359D | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | |
Mean | 0 | 0 | 1 | 0 | 0 | 0 | 0,3 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material does not have irritation potential
- Executive summary:
Application of 0,5 g of oiled Red Phosphorus to intact and abraded skin of 6 New Zealand White rabbits for 24 hours did not produce signs of irritation. The mean primary irritation score (intact akin) was 0 which indicates that the test material does not have irritation potential. Clinical signs indicative of systemic toxicity were not observed during the course of this study.
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