Registration Dossier
Registration Dossier
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EC number: 225-511-8 | CAS number: 4890-85-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- A reliable secondary source, summaring FEB pharmaco-toxicological properties, was used. However, the primary sources were not revisited in order to verify their contents; for this reason reliability score 2 was used. The used secondary source has been updated on September, 2013; therefore it covers the most updated literature on the substance.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Diphenylacetic acid
- Bibliographic source:
- CHEMID
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Test type:
- other: no data
- Limit test:
- no
Test material
- Reference substance name:
- Diphenylacetic acid
- EC Number:
- 204-185-0
- EC Name:
- Diphenylacetic acid
- Cas Number:
- 117-34-0
- IUPAC Name:
- diphenylacetic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 5 540 mg/kg bw
- Based on:
- other: Diphenylacetic acid
- Clinical signs:
- BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
BEHAVIORAL: ATAXIA
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 on rat is 5540 mg/kg.
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