Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP Guideline study

Data source

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)

Test material

Constituent 1
Chemical structure
Reference substance name:
(3Z)-1-benzofuran-3(2H)-one O-methyloxime
Cas Number:
208711-51-7
Molecular formula:
C9H9NO2
IUPAC Name:
(3Z)-1-benzofuran-3(2H)-one O-methyloxime
Constituent 2
Reference substance name:
(3Z)-1-benzofuran-3(2H)-one O-methyloxime
IUPAC Name:
(3Z)-1-benzofuran-3(2H)-one O-methyloxime

Test animals / tissue source

Species:
rabbit
Strain:
Himalayan

Test system

Vehicle:
unchanged (no vehicle)
Duration of treatment / exposure:
24, 48, 72 hours
Observation period (in vivo):
4 days
Number of animals or in vitro replicates:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: conjuct./redness
Basis:
mean
Time point:
other: 72 h
Score:
0
Max. score:
2
Reversibility:
fully reversible within: 4 days
Irritation parameter:
other: conjuct./chemosis
Basis:
mean
Time point:
other: 72 h
Score:
0
Max. score:
1
Reversibility:
fully reversible within: 4 days
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 72 h
Score:
0
Max. score:
0
Reversibility:
fully reversible
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 72 h
Score:
0
Max. score:
0
Reversibility:
fully reversible

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU