Registration Dossier
Registration Dossier
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EC number: 939-173-0 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study
Data source
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
Test material
- Reference substance name:
- (3Z)-1-benzofuran-3(2H)-one O-methyloxime
- Cas Number:
- 208711-51-7
- Molecular formula:
- C9H9NO2
- IUPAC Name:
- (3Z)-1-benzofuran-3(2H)-one O-methyloxime
- Reference substance name:
- (3Z)-1-benzofuran-3(2H)-one O-methyloxime
- IUPAC Name:
- (3Z)-1-benzofuran-3(2H)-one O-methyloxime
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- Himalayan
Test system
- Type of coverage:
- semiocclusive
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 14 days
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Erythema/Eschar
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 1
- Max. score:
- 2
- Remarks on result:
- other: Due to the red colour of the TS observation of erythema was not possible 72 hours after patch removal. No signs of systemic intolerances. Changes not fully reversible within an observation period of 14 days.
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 0
- Max. score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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