Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 433-480-9 | CAS number: 623-53-0
Summary of results:
Oral administration of the test material, MEC to rats for a period of twenty-eight consecutive days at dose levels of up to 1000 mg/kg/day produced minor treatment-related changes confined to 1000 mg/kg/day females. No such effects were demonstrated in males treated with 1000 mg/kg/day or animals of either sex treated with 150 mg/kg/day or 15 mg/kg/day.
Clinical observations: Clinical signs were confined to 1000 mg/kg/d females who showed an isolated instance of increased salivation detected up to ten minutes after dosing on Day 5 and hunched posture from Day 14 onwards. It was further concluded in the study report that in view of the isolated nature and absence of supporting evidence to the contrary these findings was considered to be of dubious toxicological significance. No treatment-related clinical signs were detected in 1000 mg/kg/day males or animals of either sex treated with 150 or 15 mg/kg/d.
Behavioural Assessements: Detailed open-field observations confirmed the clinical signs of hunched posture detected in 1000 mg/kg/d females from Week 2 onwards. No effects were detected in 1000 mg/kg/d males or in animals of either sex treated with 150 or 15 mg/kg/d. All remaining inter and intra group differences in behavioural scores were considered to be a result of normal variation for rats of the strain and age used and were of no toxicological importance.
Functional Performance Tests: There were no treatment-related changes in the functional performance parameters measured. Statistical analysis of the data revealed no significant intergroup differences
Sensory Reactivity Assessments: There were no treatment-related changes in sensory reactivity. All inter and intra group differences in sensory reactivity scores were considered a result of normal variation for rats of the strain and age used and were of no toxicological importance. Statistical analysis of the quantitative data revealed no significant intergroup differences.
Blood Chemistry: There were no treatment-related changes detected in the blood chemical parameters measured. Statistical analysis of the data revealed no significant intergroup differences.
Necropsy: No treatment-related macroscopic abnormalities were detected.
Histopathology: There were no treatment-related microscopic changes observed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again