Carbonic acid, ethyl methyl ester

Adsorption / desorption

Administrative data

Endpoint:

adsorption / desorption: screening

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: official guideline method, GLP with certificate, good documentation, identity of substance clear but no details on its purity

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2001

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))

Version / remarks:

; detail in study report: according to OECD draft document (August 1999): Estimation of the Adsorption Coefficient (Koc) on Soil and Sewage Sludge using High Performance Liquid Chromatography (HPLC).

GLP compliance:

yes (incl. QA statement)

Type of method:

HPLC estimation method

Media:

soil/sewage sludge

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

433-480-9

EC Name:

-

Cas Number:

623-53-0

Molecular formula:

C4H8O3

IUPAC Name:

ethyl methyl carbonate

Details on test material:

Sponsor's identification: MEC
Description: clear colourless liquid
Batch number: 00925
Date received: 11.27.2000
Storage conditions: room temperature in the dark until 01.16.2001, thereafter at 4 °C in the dark

Remark of the author of this IUCLID dossier concerning the substance identity:
Every page of the copy of the study report contains an annotation referring to the data sharing agreement in place between the licensee that uses this study report and the data owner. In this data sharing agreement the identity of the chemical substance is specified with "Ethyl Methyl Carbonate - EC No. 433-480-9, CAS Nr. 623-53-0".

Study design

Test temperature:

40 °C (Column temperature, Refractive index detector temperature)

HPLC method

Details on study design: HPLC method:

HPLC System: Waters 2690, incorporating Waters 410 refractive index detector, autosampler and workstation
Column: Phenosphere 5 µ Next CN (250 x 4.6 mm id)
Column temperature: 40 °C
Mobile phase: methanol:water (55:45 v/v)
pH of mobile phase: 5.2
Flow-rate: 1 mL/min
Injection volume: 50 µL
Refractive index detector temperature: 40 °C

Batch equilibrium or other method

Details on sampling:

Test material (0.5246 g) was diluted to 100 mL with mobile phase

Results and discussion

Adsorption coefficient

Type:

Koc

Value:

1.58

Temp.:

40 °C

Remarks on result:

other: log10 Koc 0.199

Any other information on results incl. tables

The draft document states that the measurement of adsorption coefficient should be carried out on substances in their ionised and unionised forms. However, in the absence of any dissociating groups the determination was performed on the material in an unionised form only.

The peak at approximately 3.4 minutes was identified as originating from the sample matrix and is not associated with the test material.

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

The adsorption coefficient (Koc) of the test material has been determined to be 1.58, log10Koc 0.199.