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Diss Factsheets
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EC number: 433-480-9 | CAS number: 623-53-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: official guideline method, GLP with certificate, good documentation, identity of substance clear with details on its purity
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- Principles of method if other than guideline:
- In the study report is stated: The test was conducted according to the "Method for Testing the Biodegradability of Chemical Substances by microorganisms" stipulated in the "Testing Methods for New Chemical Substances" (July 13, 1974, Kanpogyo No. 5, Planning and Coordination Bureau, Environment Agency, Yakuhatu No. 615, Pharmaceutical Affairs Bureau, Ministry of Health and Welfare, and 49 Kikyoku No. 392, Basic Industry Bureau, Ministry of International Trade and Industry, Japan). The test method is very similar to one stipulated in the OECD Guideline for Testing of Chemicals "Ready Biodegradability: 301C, Modified MITI Test (I)" (Revised July 17, 1992).
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- -
- EC Number:
- 433-480-9
- EC Name:
- -
- Cas Number:
- 623-53-0
- Molecular formula:
- C4H8O3
- IUPAC Name:
- ethyl methyl carbonate
- Details on test material:
- Test material as stated in study report ("Name"): Ethyl methyl carbonate
Molecular formula: C4H8O3
Molecular weight: 104.11
Purity: 99.8 %
Supplier of the test substance: Ube Industries, Ltd.
Lot number of the test substance: MEC-27452
Identification: Two IR spectra, obtained from the sponsor and from our laboratory were confirmed to be identical
Storage: Chilled dark place
Remark of the author of this IUCLID dossier concerning the substance identity:
Every page of the copy of the study report contains an annotation referring to the data sharing agreement in place between the licensee that uses this study report and the data owner. In this data sharing agreement the identity of the chemical substance is specified with "Ethyl Methyl Carbonate - EC No. 433-480-9, CAS Nr. 623-53-0".
Constituent 1
Study design
- Oxygen conditions:
- anaerobic
- Remarks:
- Culture apparatus: Closed system oxygen consumption measuring apparatus
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- Concentration of activated sludge: 30 mg/L (as the concentration of suspended solid)
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Details on study design:
- Test solutions: (a) Water + test substance (297 mL of purified water mixed with 3 mL of 10 g/L test substance) (n=1, Vessel No. 2)
(b) Sludge + test substance (297 mL of basal culture medium mixed with 3 mL of 10 g/L test substance) (n=3, Vessel No. 3, 4 and 5)
(c) Sludge + aniline (300 mL of basal culture medium added with 29.5 µL (30.0 mg) aniline) (n=1, Vessel No. 1)
(d) Control blank (300 mL of basal culture medium without test substance or aniline) (n=1, Vessel No. 6)
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (TOC removal)
- Value:
- 92
- Sampling time:
- 28 d
- Parameter:
- other: Biodegradation by biochemical oxygen demand (BOD)
- Value:
- 98
- Sampling time:
- 28 d
- Parameter:
- % degradation (test mat. analysis)
- Remarks:
- Determination of test substance by means of a gas chromatography (GC)
- Value:
- 100
- Sampling time:
- 28 d
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- In the study report a final false statement is given: "It is concluded that the test substance was not biodegraded by microorganisms under the present test conditions." The actual results of the study point to ready biodegradability. After inquiring about the validity of the given statement the author of this IUCLID dossier got the confirmation from the data owner that this is a false statement in the study report. The substance is regarded as ready biodegradable by microorganisms as it degraded by > 70 % within 28 d (in accordance with: Guidance on information requirements and chemical safety assessment, May 2008; REGULATION (EC) No 1272/2008, 4.1.2.9. Rapid degradability of organic substances (16 Dec 2008))
Chapter R.7b: Endpoint specific guidance
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.