Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 225-533-8 | CAS number: 4904-61-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: A reliable study (OECD 401) is available. Oral LD50 is equal to 4400 mg/kg bw in rats.
Acute inhalation toxicity : Two reliable study are available, test item was tested as aerosol in rats. LC50 (4) > 8.1 mg/L.
Acute dermal toxicity: A data is available but this study is not assignable because data is unpublished. This study showed a dermal LD50 > 3520 mg/kg in rabbits.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 4 400 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 8.1 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 3 520 mg/kg bw
Additional information
Acute toxicity : oral
In a determination of the acute oral toxicity on male and female rats it was found that the LD50 of the test item 1,5,9-cyclododecatriene is 4400 mg/kg bw. 30 minutes after application animals showed restlessness, rough skin, decrease of responsiveness, hunched posture, diarrhoea, moderate to severe tremors, convulsions, sedation, prone position. Those animals surviving the test appeared normal after 5 days at the latest. There was practically no influence on the increase in body weight. Dissection at the end of the experiment revealed redness of the mucosa of the gut and stomach and an accumulation of liquor. Animals which survived the study showed no pathological changes.Under the conditions of this study the acute toxicity of 1,5,9-cyclododecatriene after oral application in rats is very low.
Acute toxicity : inhalation
In the first reliable study, two groups of 6 male rats each were exposed nose-only for a single, 4-hour periode to vapors of the test item 1,5,9 -Cyclododecatriene in air at chamber vapor concentrations of 6.1 or 8.1 mg/l. Mortality was 1/6 in the high dose group. Clinical signs noted in rats from both exposures included included ocular and nasal discharges, irregular respiration, abnormal gait or mobility, and tremors. Additionally, the rats exposed to 8.1 mg/l exhibited aggressive behavior and vocalization. Tremors were observed only on test day 1 in both groups. Abnormal gait or mobility was observed only on test day 1 in rats exposed to 6.1 mg/l and up to 3 days following exposure in rats exposed to 8.1 mg/l. No clinical signs of toxicity were observed after day 4 following exposure.
Therefore it is concluded that the LC50 for male rats is greater than 8.1 mg/l air for the test item 1,5,9-cyclododecatriene under the conditions of the study.
In the second study, male rats were exposed whole body for a single, 6 hour periode to vapors of the test item 1,5,9-cyclododecatriene in air at chamber vapor concentrations of 5.0, 6.0, 7.0, 8.0, 8.5, 9.0 and10.0 mg/l. Mortality was 0/10; 1/10; 5/10; 5/20; 4/10; 3/10; 18/20 within the exposure groups (5.0, 6.0, 7.0, 8.0, 8.5, 9.0 and 10.0 mg/l) and 92 % died during exposure. Clinical signs noted in rats from all exposures included gasping, twiching, and severe muscle spasms.
In general, recovery of the animals was complete by the third day following exposure. Under the conditions of the study it is concluded that the LC50 for male rats is 8.2 mg/l (95% confidence interval = 7.5 - 8.9) for the test item 1,5,9-cyclododecatriene.Acute toxicity : dermal
Two rats of each sex (aged 12 -13 weeks) were used at each dose level (2, 3 or 4 mL/kg). The test substance was placed onto the shorn dorso-lumbar skin, and bandaged to contact the skin using an impermeable dressing of aluminium foil and waterproof plaster. The rats were housed individually over the 24 -hour exposure period, during which time they were deprived of food, but allowed water ad libitum. After 24 hours, the dressings were removed and the exposed area was washed with a tepid dilute detergent solution. The rats were then housed 3/cage, egnders separate, and observed for signs of intoxiciation during the following 9 days. None of the rabbits died during the test. All the rats had eschar on their backs when the occlusive dressing had been removed.
Under the conditions of this study the acute toxicity of 1,5,9-cyclododecatriene after dermal application in rabbits is very low with a LD50 higher than 3520 mg/kg (4 mL/kg).
Justification for classification or non-classification
Proposed self-classification
- Regulation (EC) No 1272/2008
Not classified
- Directive 67/548/EEC
Not classified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.