Registration Dossier
Registration Dossier
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EC number: 225-533-8 | CAS number: 4904-61-4
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)
- GLP compliance:
- no
Test material
- Reference substance name:
- Cyclododeca-1,5,9-triene
- EC Number:
- 225-533-8
- EC Name:
- Cyclododeca-1,5,9-triene
- Cas Number:
- 4904-61-4
- Molecular formula:
- C12H18
- IUPAC Name:
- cyclododeca-1,5,9-triene
- Details on test material:
- IUCLID4 Test substance: other TS: 1,5,9-cyclododecatriene, purity 94 % (trans, trans, trans form)
Origin: Tokyo Kasei Kogyo Co., Ltd.
Constituent 1
- Radiolabelling:
- no
Sampling and analysis
- Details on sampling:
- - Sampling in weeks 1, 2, 4, 6, 8 and 10 (both fish and water)
Test solutions
- Vehicle:
- yes
- Details on preparation of test solutions, spiked fish food or sediment:
- - Vehicle / dispersant: HCO-20, HCO-40
Test organisms
- Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISMS
- Size of fish: average weight 26.2 g, average total length 9.8 cm
- Lipid content of test organism: 5 % average
Study design
- Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 70 d
Test conditions
- Test temperature:
- 25 °C +/- 1 °C
- Details on test conditions:
- EXPOSURE CONDITIONS
- Exposure vessel: 100 l glass tank, 1155 l/day flow-through
- Results based on measured concentrations in water - Nominal and measured concentrations:
- Concentration of test substance: 1 µg/l, 10 µg/l (nominal)
- Reference substance (positive control):
- no
Results and discussion
Bioaccumulation factoropen allclose all
- Type:
- BCF
- Value:
- 2 630 - 12 500
- Basis:
- whole body w.w.
- Remarks on result:
- other: Conc.in environment / dose:10 µg/L
- Type:
- BCF
- Value:
- 1 920 - 14 800
- Basis:
- whole body w.w.
- Remarks on result:
- other: Conc.in environment / dose:1 µg/L
Depuration
- Elimination:
- no
Any other information on results incl. tables
- Measured vs nominal concentrations:
nominal: 1 2 4 6 8 10 weeks
10 ug/l: 5.54 5.59 6.12 6.49 6.90 6.95 ug/l
1 ug/l: 0.442 0.511 0.576 0.617 0.650 0.666 ug/l
- Bioconcentration factors
Range at 10 ug/l: BCF 2630-12500
Range at 1 ug/l: BCF 1920-14800
(2 determinations for each concentration and each time point listed above)
Applicant's summary and conclusion
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