Registration Dossier
Registration Dossier
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EC number: 202-879-8 | CAS number: 100-69-6
Carcinogenicity
Administrative data
Description of key information
Key study: Study well documented, meets generally accepted scientific principles, acceptable for assessment. 2 -vinylpyridine was considered to be non–tumourigenic in mice.
Key value for chemical safety assessment
Justification for classification or non-classification
Based on available data, 2 -vinylpyridine is not classified for carcinogenicity according to CLP Regulation (EC) no 1272/2008.
Additional information
Key study: 2 -vinylpyridine was given at a total dose of 200 µmol by i.p. injection to 25 female A/J mice. Each mouse received an i.p. injection of the test compound in olive oil 3 times weekly for a total of 20 injections. A positive control (treated with N-nitrosamine NNK) and a negative control (treated with olive oil) were included in the experiment. Twenty weeks after the last injection the mice were killed and a complete autopsy of each mouse was performed. None of the animals treated with the test substance developed significant numbers of lung adenoma or any other type of tumour. By contrast, the positive control induced a high indicence of lung adenoma in the A/J mice. On the basis of these results, 2 -vinylpyridine can be considered as non-tumourigenic in mice.
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