Registration Dossier
Registration Dossier
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EC number: 200-826-3 | CAS number: 74-97-5
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Weight of evidence: Bacterial reverse mutation assays (Ames tests), with and without metabolic activation, and a Chromosome aberration test have been conducted for bromochloromethane. Results of these tests have been considered positive evidence of mutagenicity. Bromochloromethane was mutagenic in Salmonella typhimurium and E.coli tests and induced sister cromatid exchange and chromosome aberrations in Chinese hamster cells in vitro. Although these in vitro studies are not sufficient for classification may offer supporting information in the event of in vivo mutagenicity data.
Short description of key information:
Weight of evidence: Experimental results from scientific articles. Only in vitro data is available. The bacterial reverse mutation assays (Ames tests) and the Chromosome aberration test indicate potential for mutagenicity.
Endpoint Conclusion: Adverse effect observed (positive)
Justification for classification or non-classification
Only in vitro studies are available for bromochloromethane. There are no studies of exposed humans and no genotoxicity tests in vivo. Thus, there are no data available that would justify classification for germ cell mutagenicity according to CLP criteria.
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