Registration Dossier
Registration Dossier
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EC number: 200-826-3 | CAS number: 74-97-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Only few data on test method reported.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 960
Materials and methods
- Principles of method if other than guideline:
- Acute dermal toxicity study using a modified Draize technique.
- GLP compliance:
- no
- Test type:
- other: not specified.
Test material
- Reference substance name:
- Bromochloromethane
- EC Number:
- 200-826-3
- EC Name:
- Bromochloromethane
- Cas Number:
- 74-97-5
- Molecular formula:
- CH2BrCl
- IUPAC Name:
- bromo(chloro)methane
- Details on test material:
- - Name of test material (as cited in study report): bromochloromethane
- Analytical purity: 99%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours.
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 4 rabbits.
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals survived after the administration of 5000 mg/kg bw.
- Clinical signs:
- other: Burn and denaturation of the skin was observed in the exposed animals.
- Gross pathology:
- Not examined.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal LD50 of bromochloromethane is determined to be > 5000 mg/kg bw.
- Executive summary:
In the present acute dermal toxicity study conducted with the test substance bromochloromethane, belly hair was clipped from the rabbits and a single application of the test substance was applied using a modified Draize technique. Four out of four rabbits survived a dose of 5000 mg/kg, and only a slight loss of body weight occurred over the observation period. Clinical observations included a burn and denaturation of the skin with occlusive application. On the basis of these results, the dermal LD50 of bromochloromethane is determined to be > 5000 mg/kg bw.
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