Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Only few data on test method reported.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1960

Materials and methods

Principles of method if other than guideline:
Acute dermal toxicity study using a modified Draize technique.
GLP compliance:
no
Test type:
other: not specified.

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): bromochloromethane
- Analytical purity: 99%

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 hours.
Doses:
5000 mg/kg
No. of animals per sex per dose:
4 rabbits.
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
All animals survived after the administration of 5000 mg/kg bw.
Clinical signs:
Burn and denaturation of the skin was observed in the exposed animals.
Body weight:
A slight loss of body weight was observed during the observation period.
Gross pathology:
Not examined.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The dermal LD50 of bromochloromethane is determined to be > 5000 mg/kg bw.
Executive summary:

In the present acute dermal toxicity study conducted with the test substance bromochloromethane, belly hair was clipped from the rabbits and a single application of the test substance was applied using a modified Draize technique. Four out of four rabbits survived a dose of 5000 mg/kg, and only a slight loss of body weight occurred over the observation period. Clinical observations included a burn and denaturation of the skin with occlusive application. On the basis of these results, the dermal LD50 of bromochloromethane is determined to be > 5000 mg/kg bw.